Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function

	Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
	Xiao, Y; Li, B; Zhou, ZC; Hancock, WW; Zhang, HT; Greene, MI
刊名	CURRENT OPINION IN IMMUNOLOGY
	2010
卷号	22 期号:5 页码:583-591
通讯作者	Greene, MI (reprint author), Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.,
英文摘要	Regulatory T cells (Tregs) are required for the maintenance of immune homeostasis as first clearly described by Herman Waldmann s laboratory Dysfunction of Treg cell, also leads to fatal autoimmunity in humans and mice Conversely the activation of different classes of Tregs operative systemically and within the cancer microenvironment can suppress host anti-tumor immune responses and promote tumor progression Therefore the development of new therapeutic approaches to regulate the activity of Treg cell, may have considerable clinical potential FOXP3 is the key transcriptional regulator of Treg development and function The activity of FOXP3 is regulated by acetylation a process catalyzed by distinct types of histone/protein acetyltransferases (HATs) that regulate the functions of many transcription factors independently of FOXP3 as well as nonhistone proteins in addition to their effects on chromatin accessibility Interactions between FOXP3 and these enzymes determine the suppressive function of FOXP3 Clearly small molecules targeting these enzymes are candidates for the regulation of Treg function in vaccines and tumor therapies
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	NUCLEAR-PROTEIN CBP ; TUMOR-BEARING HOSTS ; I-J ANTIBODIES ; T-CELLS ; TGF-BETA ; COACTIVATORS P300 ; IMMUNE-RESPONSE ; CO-REPRESSOR ; SCURFY MOUSE ; DNA-BINDING
收录类别	SCI
语种	英语
WOS记录号	WOS:000284564300006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1001]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xiao, Y,Li, B,Zhou, ZC,et al. Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function[J]. CURRENT OPINION IN IMMUNOLOGY,2010,22(5):583-591.
APA	Xiao, Y,Li, B,Zhou, ZC,Hancock, WW,Zhang, HT,&Greene, MI.(2010).Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.CURRENT OPINION IN IMMUNOLOGY,22(5),583-591.
MLA	Xiao, Y,et al."Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function".CURRENT OPINION IN IMMUNOLOGY 22.5(2010):583-591.