microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia

	microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia
	Han, YC; Park, CY; Bhagat, G; Zhang, JP; Wang, YL; Fan, JB; Liu, MF; Zou, YR; Weissman, IL; Gu, H
刊名	JOURNAL OF EXPERIMENTAL MEDICINE
	2010
卷号	207 期号:3 页码:475-489
通讯作者	Gu, H (reprint author), Columbia Univ Coll Phys & Surg, Dept Microbiol & Immunol, 630 W 168th St, New York, NY 10032 USA.,hg2065@columbia.edu
英文摘要	The function of microRNAs (miRNAs) in hematopoietic stem cells (HSCs), committed progenitors, and leukemia stem cells (LSCs) is poorly understood. We show that miR-29a is highly expressed in HSC and down-regulated in hematopoietic progenitors. Ectopic expression of miR-29a in mouse HSC/progenitors results in acquisition of self-renewal capacity by myeloid progenitors, biased myeloid differentiation, and the development of a myeloproliferative disorder that progresses to acute myeloid leukemia (AML). miR-29a promotes progenitor proliferation by expediting G1 to S/G2 cell cycle transitions. miR-29a is overexpressed in human AML and, like human LSC, miR-29a-expressing myeloid progenitors serially transplant AML. Our data indicate that miR-29a regulates early hematopoiesis and suggest that miR-29a initiates AML by converting myeloid progenitors into self-renewing LSC.
学科主题	Immunology ; Research & Experimental Medicine
类目[WOS]	Immunology ; Medicine, Research & Experimental
关键词[WOS]	STEM-CELLS ; TRANSCRIPTIONAL REPRESSOR ; HUMAN CANCERS ; DIFFERENTIATION ; EXPRESSION ; HBP1 ; PROTEIN ; IDENTIFICATION ; SIGNATURES ; HIERARCHY
收录类别	SCI
语种	英语
WOS记录号	WOS:000275593900005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/974]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Han, YC,Park, CY,Bhagat, G,et al. microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2010,207(3):475-489.
APA	Han, YC.,Park, CY.,Bhagat, G.,Zhang, JP.,Wang, YL.,...&Gu, H.(2010).microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia.JOURNAL OF EXPERIMENTAL MEDICINE,207(3),475-489.
MLA	Han, YC,et al."microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia".JOURNAL OF EXPERIMENTAL MEDICINE 207.3(2010):475-489.