Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene

	Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene
	Fan, JK; Wei, N; Ding, MA; Gu, JF; Liu, XR; Li, BH; Qi, R; Huang, WD; Li, YH; Xiong, XQ
刊名	INTERNATIONAL JOURNAL OF CANCER
	2010
卷号	127 期号:3 页码:707-717
关键词	DD3 IL-24 oncolytic adenovirus apoptosis prostate cancer
通讯作者	Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,runshengli2007@gmail.com ; xyliu@sibs.ac.cn
英文摘要	Prostate cancer (PCa) is the second leading cause of cancer-related deaths in Western male population. Previous studies have demonstrated that differential display code 3 (DD3 or DD3(PCA3)) is one of the most PCa-specific genes; therefore, it has been used as a clinical diagnostic marker for PCa. In this study, we constructed an oncolytic adenovirus Ad.DD3-E1A by using the minimal DD3 promoter to replace the native viral promoter of E1A gene. In addition, Ad.DD3-E1A was armed with therapeutic gene IL-24 to enhance its antitumor activity. The resulting adenovirus, Ad.DD3-E1A-IL-24, demonstrated PCa specificity and excellent antitumor effect. Further analyses on its antitumor mechanism revealed that it has the capacity to induce apoptosis in PCa cells and inhibit angiogenesis. These results suggest that Ad.DD3-E1A-IL-24 is a promising antitumor agent that may be able to be used in the future as a treatment for PCa.
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	DIFFERENTIATION-ASSOCIATED GENE-7 ; MELANOMA-DIFFERENTIATION ; REPLICATING ADENOVIRUS ; TUMOR-CELLS ; MDA-7/IL-24 ; THERAPY ; GROWTH ; CARCINOMA ; MDA-7 ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000279131300022
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/969]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Fan, JK,Wei, N,Ding, MA,et al. Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene[J]. INTERNATIONAL JOURNAL OF CANCER,2010,127(3):707-717.
APA	Fan, JK.,Wei, N.,Ding, MA.,Gu, JF.,Liu, XR.,...&Liu, XY.(2010).Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene.INTERNATIONAL JOURNAL OF CANCER,127(3),707-717.
MLA	Fan, JK,et al."Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene".INTERNATIONAL JOURNAL OF CANCER 127.3(2010):707-717.