Sorting of neuropeptides and neuropeptide receptors into secretory pathways

	Sorting of neuropeptides and neuropeptide receptors into secretory pathways
	Zhang, X; Bao, L; Ma, GQ
刊名	PROGRESS IN NEUROBIOLOGY
	2010
卷号	90 期号:2 页码:276-283
关键词	Neuropeptide Neuropeptide receptor Opioid receptor Substance P Sorting mechanism Secretory pathway
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn ; baolan@sibs.ac.cn
英文摘要	There are two major secretory pathways in neurons, the regulated pathway and the constitutive pathway. Neuropeptides and other regulated secretory proteins are known to be sorted into large dense-core vesicles of the regulated pathway in the trans-Golgi network and are secreted upon stimulus-induced increases in intracellular Ca(2+). The newly synthesized cell surface receptors are usually sorted into microvesicles of the constitutive pathway and inserted into the plasma membrane by spontaneous exocytosis. Small-diameter sensory neurons in dorsal root ganglia and pheochromocytoma cells express neuropeptides (e.g., substance P) and several neuropeptide receptors including opioid receptors. The p,opioid receptors are delivered to the cell surface through the constitutive pathway, whereas another type of opioid receptor, the delta-opioid receptor, is often found in the membrane of large dense-core vesicles and can be inserted into the plasma membrane when exocytosis occurs. Recent studies show that sequences with opposite electrical polarity within the prohormones of substance P are essential for their sorting into large dense-core vesicles. Moreover, the delta-opioid receptor is sorted into large dense-core vesicles by its interaction with protachykinin, a prohormone of substance P. These findings provide insight into the molecular mechanisms that determine the sorting and trafficking of neuropeptides and neuropeptide receptors in neurons. (C) 2009 Elsevier Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	DELTA-OPIOID RECEPTORS ; RAT SPINAL-CORD ; DORSAL-ROOT GANGLIA ; VENTROLATERAL PERIAQUEDUCTAL GRAY ; HYDROPHOBIC-HYDROPHILIC BALANCE ; PROTEIN-COUPLED RECEPTORS ; GREEN FLUORESCENT PROTEIN ; PH-DEPENDENT AGGREGATION ; PRIMARY SENSORY NEURONS ; CENTRAL-NERVOUS-SYSTEM
收录类别	SCI
语种	英语
WOS记录号	WOS:000276293700016
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/953]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, X,Bao, L,Ma, GQ. Sorting of neuropeptides and neuropeptide receptors into secretory pathways[J]. PROGRESS IN NEUROBIOLOGY,2010,90(2):276-283.
APA	Zhang, X,Bao, L,&Ma, GQ.(2010).Sorting of neuropeptides and neuropeptide receptors into secretory pathways.PROGRESS IN NEUROBIOLOGY,90(2),276-283.
MLA	Zhang, X,et al."Sorting of neuropeptides and neuropeptide receptors into secretory pathways".PROGRESS IN NEUROBIOLOGY 90.2(2010):276-283.