Immunopathologies linked to integrin signalling

	Immunopathologies linked to integrin signalling
	Wang, HY; Lim, D; Rudd, CE
刊名	SEMINARS IN IMMUNOPATHOLOGY
	2010
卷号	32 期号:2 页码:173-182
关键词	Integrins LFA-1 LAD SLP-76 SKAP1 RapL Kindlin-3
通讯作者	Wang, HY (reprint author), Univ Cambridge, Dept Pathol, Cell Signalling Sect, Tennis Court Rd, Cambridge CB2 1QP, England.,hw300@cam.ac.uk
英文摘要	Integrin binding to ligand plays essential roles in the differentiation and function of mammalian cells. beta 2 integrins in leukocytes are needed for migration to sites of inflammation and in lymph nodes as well as for cellular events such as phagocytosis and the formation of the conjugates between T cells and antigen-presenting cells. In T cells, integrin adhesion is activated primarily by the antigen-receptor (TCR complex) and chemokines in a process known as 'inside-out' signalling. Great progress has been made in identifying mutations that are responsible for leukocyte adhesion deficiency (LAD) syndromes, a disorder that presents with an impaired ability to clear pathogens and recurrent life-threatening infections. LAD mutations have been identified with defects in integrins, fucosylation and in the new intracellular mediator kindlin-3. Here, we review the key players in the 'inside-out' and 'outside-in' signalling pathways that will serve as new potential targets in the design of novel therapeutics to treat various immunodeficiencies.
学科主题	Immunology; Pathology
类目[WOS]	Immunology ; Pathology
关键词[WOS]	LEUKOCYTE ADHESION DEFICIENCY ; T-CELL ; STRUCTURAL BASIS ; ACTIN CYTOSKELETON ; INTERLEUKIN-2 TRANSCRIPTION ; LFA-1-DEFICIENT MICE ; ADAPTER PROTEIN ; FOCAL ADHESIONS ; IN-VIVO ; ACTIVATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000277556700009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/945]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, HY,Lim, D,Rudd, CE. Immunopathologies linked to integrin signalling[J]. SEMINARS IN IMMUNOPATHOLOGY,2010,32(2):173-182.
APA	Wang, HY,Lim, D,&Rudd, CE.(2010).Immunopathologies linked to integrin signalling.SEMINARS IN IMMUNOPATHOLOGY,32(2),173-182.
MLA	Wang, HY,et al."Immunopathologies linked to integrin signalling".SEMINARS IN IMMUNOPATHOLOGY 32.2(2010):173-182.