Expression levels of microRNAs are not associated with their regulatory activities

	Expression levels of microRNAs are not associated with their regulatory activities
	Liang, Z; Zhou, H; Zheng, HR; Wu, JR
刊名	BIOLOGY DIRECT
	2011
卷号	6 期号:1 页码:43-43
关键词	MicroRNA microRNA activity microRNA expression
通讯作者	Liang, Z (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China.,liangzhi@ustc.edu.cn ; hrzheng@ustc.edu.cn ; wujr@sibs.ac.cn
英文摘要	MicroRNAs (miRNAs) regulate their targets by triggering mRNA degradation or translational repression. The negative relationship between miRNAs and their targets suggests that the regulatory effect of a miRNA could be determined from the expression levels of its targets. Here, we investigated the relationship between miRNA activities determined by computational programs and miRNA expression levels by using data in which both mRNA and miRNA expression from the same samples were measured. We found that different from the intuitive expectation one might have, miRNA activity shows very weak correlation with miRNA expression, which indicates complex regulating mechanisms between miRNAs and their target genes.
学科主题	Life Sciences & Biomedicine - Other Topics
类目[WOS]	Biology
关键词[WOS]	MESSENGER-RNA EXPRESSION ; HUMAN CANCERS ; BINDING ; ACCESS
收录类别	SCI
语种	英语
WOS记录号	WOS:000295713100001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/901]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liang, Z,Zhou, H,Zheng, HR,et al. Expression levels of microRNAs are not associated with their regulatory activities[J]. BIOLOGY DIRECT,2011,6(1):43-43.
APA	Liang, Z,Zhou, H,Zheng, HR,&Wu, JR.(2011).Expression levels of microRNAs are not associated with their regulatory activities.BIOLOGY DIRECT,6(1),43-43.
MLA	Liang, Z,et al."Expression levels of microRNAs are not associated with their regulatory activities".BIOLOGY DIRECT 6.1(2011):43-43.