Current understanding of Th2 cell differentiation and function

	Current understanding of Th2 cell differentiation and function
	Li, ZH; Zhang, Y; Sun, B
刊名	PROTEIN & CELL
	2011
卷号	2 期号:8 页码:604-611
关键词	type 2 helper T cell (Th2) asthma IL-9 secreting T cell (Th9) T follicular helper cell
通讯作者	Sun, B (reprint author), Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn
英文摘要	Helper T cell (Th) has been identified as a critical immune cell for regulating immune response since 1980s. The type 2 helper T cell (Th2), characterized by the production of interleukin-4 (IL-4), IL-5 and IL-13, plays a critical role in immune response against helminths invading cutaneous or mucosal sites. It also has a functional role in the pathophysiology of allergic diseases such as asthma and allergic diarrhea. Currently, most studies have shed light on Th2 cell function and behavior in specific diseases, such as asthma and helminthes inflammation, but not on Th2 cell itself and its differentiation. Based on different cytokines and specific behavior in recent research, Th2 cell is also regarded as new subtypes of T cell, such as IL-9 secreting T cell (Th9) and CXCR5(+) T follicular helper cells. Here, we will discuss the latest view of Th2 cell towards their function and the involvement of Th2 cell in diseases.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	FOLLICULAR-HELPER-CELLS ; CD4(+) T-CELLS ; INTERFERON-REGULATORY FACTOR-4 ; CXC CHEMOKINE RECEPTOR-5 ; ANTIGEN-PRESENTING CELLS ; TRANSCRIPTION FACTOR ; LINEAGE COMMITMENT ; GERMINAL-CENTERS ; GENE-EXPRESSION ; TGF-BETA
收录类别	SCI
语种	英语
WOS记录号	WOS:000310521900002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/844]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, ZH,Zhang, Y,Sun, B. Current understanding of Th2 cell differentiation and function[J]. PROTEIN & CELL,2011,2(8):604-611.
APA	Li, ZH,Zhang, Y,&Sun, B.(2011).Current understanding of Th2 cell differentiation and function.PROTEIN & CELL,2(8),604-611.
MLA	Li, ZH,et al."Current understanding of Th2 cell differentiation and function".PROTEIN & CELL 2.8(2011):604-611.