LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor

	LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor
	Gao, YJ; Ge, GX; Ji, HB
刊名	PROTEIN & CELL
	2011
卷号	2 期号:2 页码:99-107
关键词	liver kinase B1 lung cancer tumor suppressor
通讯作者	Ji, HB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,gxge@sibs.ac.cn
英文摘要	Lung cancer is featured with high mortality, with a 15% five-year survival rate worldwide. Genetic alterations, such as loss of function of tumor suppressor genes, frequently contribute to lung cancer initiation, progression and metastasis. Liver kinase B1 (LKB1), as a serine/threonine kinase and tumor suppressor, is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process, especially lung cancer progression and metastasis. This review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis, emphasizing on LKB1 downstream signaling pathways and biological functions. We will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	PEUTZ-JEGHERS-SYNDROME ; ACTIVATED PROTEIN-KINASE ; HEMATOPOIETIC STEM-CELLS ; CANCER PROGRESSION ; SOMATIC MUTATIONS ; KNOCKOUT MICE ; GENE ; ADENOCARCINOMAS ; LKB1/STK11 ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000310519500004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/755]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Gao, YJ,Ge, GX,Ji, HB. LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor[J]. PROTEIN & CELL,2011,2(2):99-107.
APA	Gao, YJ,Ge, GX,&Ji, HB.(2011).LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.PROTEIN & CELL,2(2),99-107.
MLA	Gao, YJ,et al."LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor".PROTEIN & CELL 2.2(2011):99-107.