Rat recombinant beta-defensin 22 is a heparin-binding protein with antimicrobial activity

	Rat recombinant beta-defensin 22 is a heparin-binding protein with antimicrobial activity
	Diao, H; Yu, HG; Sun, F; Zhang, YL; Tanphaichitr, N
刊名	ASIAN JOURNAL OF ANDROLOGY
	2011
卷号	13 期号:2 页码:305-311
关键词	epididymis rat recombinant protein sperm
通讯作者	Diao, H (reprint author), Shanghai Inst Planned Parenthood Res, NPFPC Key Lab Contracept & Devices, Shanghai 200032, Peoples R China.,diaohua77@hotmail.com
英文摘要	Approximately 40-50 beta-defensins are predominantly expressed in the male reproductive system of mammals. This selective expression raises the question as to the roles of these molecules in innate immunity and fertility in the male reproductive tract. Rat beta-defensin 22 is an epididymis-specific beta-defensin expressed in segments 12-14 of the epididymis. This protein contains both beta-defensin and lectin signature sequences, yet its antimicrobial activity and carbohydrate-binding ability have not been shown. We herein demonstrated the antimicrobial activity of recombinant rat beta-defensin 22 against Escherichia coli and Candida albicans. Its lectin-like activity was also investigated by demonstrating its binding ability with heparin beads. This heparin-binding activity implies some potential roles for this defensin in determining the fertilisation capabilities of sperm. Asian Journal of Andrology (2011) 13, 305-311; doi:10.1038/aja.2010.93; published online 13 December 2010
学科主题	Endocrinology & Metabolism ; Urology & Nephrology
类目[WOS]	Andrology ; Urology & Nephrology
关键词[WOS]	C-TYPE LECTIN ; PLASMA-MEMBRANE ; HUMAN-SPERMATOZOA ; PEPTIDES ; EPIDIDYMIS ; MOUSE ; GLYCOSAMINOGLYCANS ; IDENTIFICATION ; GLYCOPROTEIN ; POLYSPERMY
收录类别	SCI
语种	英语
WOS记录号	WOS:000288074400032
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/742]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Diao, H,Yu, HG,Sun, F,et al. Rat recombinant beta-defensin 22 is a heparin-binding protein with antimicrobial activity[J]. ASIAN JOURNAL OF ANDROLOGY,2011,13(2):305-311.
APA	Diao, H,Yu, HG,Sun, F,Zhang, YL,&Tanphaichitr, N.(2011).Rat recombinant beta-defensin 22 is a heparin-binding protein with antimicrobial activity.ASIAN JOURNAL OF ANDROLOGY,13(2),305-311.
MLA	Diao, H,et al."Rat recombinant beta-defensin 22 is a heparin-binding protein with antimicrobial activity".ASIAN JOURNAL OF ANDROLOGY 13.2(2011):305-311.