Mitogen-activated protein kinases in hepatocellular carcinoma development

	Mitogen-activated protein kinases in hepatocellular carcinoma development
	Min, LH; He, BK; Hui, LJ
刊名	SEMINARS IN CANCER BIOLOGY
	2011
卷号	21 期号:1 页码:42297
关键词	MAPKs Hepatocellular carcinoma (HCC) Proliferation Apoptosis Inflammation Targeted therapy
通讯作者	Hui, LJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Yueyang Rd 320, Shanghai 200031, Peoples R China.,ljhui@sibs.ac.cn
英文摘要	Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs), comprising a family of serine and threonine kinases of ERK, JNK, and p38, are important signaling components which convert external stimuli into a wide range of cellular responses, such as proliferation, survival, differentiation and migration. Due to their essential roles in these cellular functions, deregulated MAPKs are often found to contribute to the development of many cancers, including HCC. Markedly, early studies on the ERK pathway have led to the development of the multikinase inhibitor Sorafenib, the first effective systemic drug for the targeted treatment of human HCC. Recently, the functions and molecular mechanisms of JNK and p38 in HCC development have also been addressed using mouse models. In this review, we discuss the latest findings regarding the ERK, JNK and p38 MAPK signaling pathways in HCC development and their potential roles as therapeutic targets for HCC. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	NF-KAPPA-B ; JUN NH2-TERMINAL KINASE ; P38-ALPHA MAP KINASE ; REGULATES CELL-MIGRATION ; YES-ASSOCIATED PROTEIN ; JNK SIGNALING PATHWAY ; TUMOR-NECROSIS-FACTOR ; VIRUS X-PROTEIN ; GROWTH IN-VITRO ; TERMINAL KINASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000288840900003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/722]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Min, LH,He, BK,Hui, LJ. Mitogen-activated protein kinases in hepatocellular carcinoma development[J]. SEMINARS IN CANCER BIOLOGY,2011,21(1):42297.
APA	Min, LH,He, BK,&Hui, LJ.(2011).Mitogen-activated protein kinases in hepatocellular carcinoma development.SEMINARS IN CANCER BIOLOGY,21(1),42297.
MLA	Min, LH,et al."Mitogen-activated protein kinases in hepatocellular carcinoma development".SEMINARS IN CANCER BIOLOGY 21.1(2011):42297.