RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non-Small-Cell Lung Cancer

	RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non-Small-Cell Lung Cancer
	Wang, R; Hu, HC; Pan, YJ; Li, Y; Ye, T; Li, CG; Luo, XY; Wang, L; Li, H; Zhang, Y
刊名	JOURNAL OF CLINICAL ONCOLOGY
	2012
卷号	30 期号:35 页码:4352-4359
通讯作者	Chen, HQ (reprint author), Fudan Univ, Shanghai Canc Ctr, 270 Dong An Rd, Shanghai 200032, Peoples R China.,hqchen1@yahoo.com
英文摘要	Purpose The RET fusion gene has been recently described in a subset of non-small-cell lung cancers (NSCLCs). Because we have limited knowledge about these tumors, this study was aimed at determining the clinicopathologic characteristics of patients with NSCLC harboring the RET fusion gene. Patients and Methods We examined the RET fusion gene in 936 patients with surgically resected NSCLC using a reverse transcriptase polymerase chain reaction (PCR) plus quantitative real-time PCR strategy, with validation using immunohistochemical and fluorescent in situ hybridization assays. A subset of 633 lung adenocarcinomas was also studied for EGFR, KRAS, HER2, and BRAF mutations, as well as ALK rearrangements. Patient characteristics, including age, sex, smoking history, stage, grade, International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of subtypes of lung adenocarcinoma, and relapse-free survival, were collected. Results Of 936 patients with NSCLC, the RET fusion gene was exclusively detected in 13 patients (11 of 633 patients with adenocarcinomas and two of 24 patients with adenosquamous cell carcinomas). Of the 13 patients, nine patients had KIF5B-RET, three patients had CCDC6-RET, and one patient had a novel NCOA4-RET fusion. Patients with lung adenocarcinomas with RET fusion gene had more poorly differentiated tumors (63.6%; P = .029 for RET v ALK, P = .007 for RET v EGFR), with a tendency to be younger (<= 60 years; 72.7%) and never-smokers (81.8%) and to have solid subtype (63.6%) and a smaller tumor (<= 3 cm) with N2 disease (54.4%). The median relapse-free survival was 20.9 months. Conclusion RET fusion occurs in 1.4% of NSCLCs and 1.7% of lung adenocarcinomas and has identifiable clinicopathologic characteristics, warranting further clinical consideration and targeted therapy investigation. J Clin Oncol 30: 4352-4359. (C) 2012 by American Society of Clinical Oncology
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	THYROID PAPILLARY CARCINOMAS ; NEVER-SMOKERS ; GENE FUSIONS ; ALK ; MUTATIONS ; ADENOCARCINOMA ; IDENTIFICATION ; REARRANGEMENTS ; PROTOONCOGENE ; GEFITINIB
收录类别	SCI
语种	英语
WOS记录号	WOS:000312195900017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/692]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, R,Hu, HC,Pan, YJ,et al. RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non-Small-Cell Lung Cancer[J]. JOURNAL OF CLINICAL ONCOLOGY,2012,30(35):4352-4359.
APA	Wang, R.,Hu, HC.,Pan, YJ.,Li, Y.,Ye, T.,...&Chen, HQ.(2012).RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non-Small-Cell Lung Cancer.JOURNAL OF CLINICAL ONCOLOGY,30(35),4352-4359.
MLA	Wang, R,et al."RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non-Small-Cell Lung Cancer".JOURNAL OF CLINICAL ONCOLOGY 30.35(2012):4352-4359.