Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy

	Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy
	Liu, XY; Li, HG; Zhang, KJ; Gu, JF
刊名	CURRENT PHARMACEUTICAL BIOTECHNOLOGY
	2012
卷号	13 期号:9 页码:1761-1767
关键词	Cancer therapy Cancer targeting Gene Viro-Therapy Trend of gene therapy Trend of virotherapy
通讯作者	Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn
英文摘要	Cancer Targeting Gene-Viro-Therapy (CTGVT) and Gene Armed Oncolytic Virus Therapy (GAOVT) both are identical by inserting an antitumor gene into an oncolytic virus. This approach has gradually become a hot topic in cancer therapy, because that CTGVT (GAOVT) has much higher antitumor than that of either gene therapy alone or oncolytic virotherapy alone. We proposed the CTGVT strategy in 1999-2001, insisted it as a long term systematic approach to be examined over 10 years and have published 68 SCI papers some in good Journals. The CD gene armed oncolytic adenovirus therapy (GAOVT) for cancer treatment with potent antitumor effect was also named in our laboratory in 2003. Several modifications to CTGVT will be carried out by our group and will be introduced briefly in this paper. Most importantly, the modifications of CTGVT usually resulted in complete eradication of xenograft tumors in nude mice. In future best antitumor drugs may emerge from the modified CTGVT strategy and not from either gene therapy or virotherapy alone.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy
类目[WOS]	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]	DIFFERENTIATION-ASSOCIATED GENE ; INCREASES ANTITUMOR-ACTIVITY ; ARMED ONCOLYTIC ADENOVIRUS ; APOPTOSIS-INDUCING LIGAND ; STEM-CELLS ; MELANOMA DIFFERENTIATION ; COLORECTAL-CANCER ; MICE ; ANTIBODY ; TRAIL
收录类别	SCI
语种	英语
WOS记录号	WOS:000305631800010
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/645]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, XY,Li, HG,Zhang, KJ,et al. Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2012,13(9):1761-1767.
APA	Liu, XY,Li, HG,Zhang, KJ,&Gu, JF.(2012).Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,13(9),1761-1767.
MLA	Liu, XY,et al."Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 13.9(2012):1761-1767.