Structural Aspects of Ubiquitin Binding Specificities

	Structural Aspects of Ubiquitin Binding Specificities
	Fu, QS; Song, AX; Hu, HY
刊名	CURRENT PROTEIN & PEPTIDE SCIENCE
	2012
卷号	13 期号:5 页码:482-489
关键词	Ubiquitin Ubiquitin-binding domain Ubiquitin-like domain Binding specificity Structural basis
通讯作者	Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn
英文摘要	Ubiquitin (Ub) is widely distributed in eukaryotic cells as its name means. There are many kinds of Ub-like proteins (for example, SUMO, NEDD8 and ISG15) and Ub-like domains (UbLs) included in multi-domain proteins. To date, a large number of Ub-binding domains (UBDs), such as UBA, CUE, UIM, ZnF, and Pru, are coming up to us with different affinities to Ub and its homologues. The binding specificities provide the basis for controlling various cellular events as well as for delivering ubiquitinated proteins to proteasome for degradation. Structural details of these UBDs and their complexes with Ub might as well show us the delicate mechanism of Ub recognition and regulation. This review summarizes recent progresses on deciphering the structure-based Ub-binding specificities, which are the importantly fundamental elements in orchestrating the ubiquitination and deubiquitination processes in eukaryotic cells.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	63-LINKED POLYUBIQUITIN CHAINS ; INTERACTING MOTIF ; DEUBIQUITINATING ENZYMES ; UBA DOMAINS ; ISOPEPTIDASE-T ; RECOGNITION ; PROTEINS ; PROTEASOME ; DEGRADATION ; SUBUNIT
收录类别	SCI
语种	英语
WOS记录号	WOS:000309978300007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/593]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Fu, QS,Song, AX,Hu, HY. Structural Aspects of Ubiquitin Binding Specificities[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2012,13(5):482-489.
APA	Fu, QS,Song, AX,&Hu, HY.(2012).Structural Aspects of Ubiquitin Binding Specificities.CURRENT PROTEIN & PEPTIDE SCIENCE,13(5),482-489.
MLA	Fu, QS,et al."Structural Aspects of Ubiquitin Binding Specificities".CURRENT PROTEIN & PEPTIDE SCIENCE 13.5(2012):482-489.