Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

	Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling
	Jin, YY; Xu, JJ; Yin, MX; Lu, Y; Hu, LX; Li, PX; Zhang, P; Yuan, ZQ; Ho, MS; Ji, HB
刊名	ELIFE
	2013
卷号	2 期号:1 页码:e00999-e00999
通讯作者	Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China.,yunzhao@sibcb.ac.cn ; rayzhang@sibcb.ac.cn
英文摘要	Chromatin remodeling processes are among the most important regulatory mechanisms in controlling cell proliferation and regeneration. Drosophila intestinal stem cells (ISCs) exhibit self-renewal potentials, maintain tissue homeostasis, and serve as an excellent model for studying cell growth and regeneration. In this study, we show that Brahma (Brm) chromatin-remodeling complex is required for ISC proliferation and damage-induced midgut regeneration in a lineage-specific manner. ISCs and enteroblasts exhibit high levels of Brm proteins; and without Brm, ISC proliferation and differentiation are impaired. Importantly, the Brm complex participates in ISC proliferation induced by the Scalloped-Yorkie transcriptional complex and that the Hippo (Hpo) signaling pathway directly restricted ISC proliferation by regulating Brm protein levels by inducing caspase-dependent cleavage of Brm. The cleavage resistant form of Brm protein promoted ISC proliferation. Our findings highlighted the importance of Hpo signaling in regulating epigenetic components such as Brm to control downstream transcription and hence ISC proliferation.
学科主题	Life Sciences & Biomedicine - Other Topics
类目[WOS]	Biology
关键词[WOS]	CHROMATIN REMODELING COMPLEX ; TUMOR-SUPPRESSOR PATHWAY ; ORGAN SIZE CONTROL ; PROMOTES APOPTOSIS ; NEURAL DEVELOPMENT ; TEAD/TEF FAMILY ; SWI/SNF COMPLEX ; GROWTH-CONTROL ; SELF-RENEWAL ; CYCLE EXIT
收录类别	SCI
语种	英语
WOS记录号	WOS:000328637700002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/496]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Jin, YY,Xu, JJ,Yin, MX,et al. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling[J]. ELIFE,2013,2(1):e00999-e00999.
APA	Jin, YY.,Xu, JJ.,Yin, MX.,Lu, Y.,Hu, LX.,...&Zhang, L.(2013).Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.ELIFE,2(1),e00999-e00999.
MLA	Jin, YY,et al."Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling".ELIFE 2.1(2013):e00999-e00999.