Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development

	Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development
	Liu, Y; Xu, XH; Chen, Q; Wang, T; Deng, CY; Song, BL; Du, JL; Luo, ZG
刊名	NATURE COMMUNICATIONS
	2013
卷号	4 期号:1 页码:2005-2005
通讯作者	Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,zgluo@ion.ac.cn
英文摘要	Polarized membrane addition is crucial for axon development and elongation during neuronal morphogenesis. This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain unclear. Here, we report that Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development. Rab10 interacts with the exon D-encoded domain of MYO5B. Downregulating the expression of MYO5B (+D) or blocking its interaction with Rab10 impairs the fission of Rab10 vesicles from trans-Golgi membranes, causes a decrease in the number of Rab10 transport carriers and inhibits axon development in cultured hippocampal neurons. Furthermore, the MYO5B-Rab10 system is required for axon development of vertebrate neocortical neurons or zebrafish retinal ganglion cells in vivo. Thus, specific interaction between Rab10 and MYO5B controls the formation of Rab10 vesicles, which is required for axon development.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	RETINAL GANGLION-CELLS ; PLASMA-MEMBRANE ; DEVELOPING NEURONS ; HIPPOCAMPAL-NEURONS ; NEURITE OUTGROWTH ; AMPA RECEPTORS ; IN-VIVO ; TRANSPORT ; COMPLEX ; VA
收录类别	SCI
语种	英语
WOS记录号	WOS:000323625200002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/490]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, Y,Xu, XH,Chen, Q,et al. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development[J]. NATURE COMMUNICATIONS,2013,4(1):2005-2005.
APA	Liu, Y.,Xu, XH.,Chen, Q.,Wang, T.,Deng, CY.,...&Luo, ZG.(2013).Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development.NATURE COMMUNICATIONS,4(1),2005-2005.
MLA	Liu, Y,et al."Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development".NATURE COMMUNICATIONS 4.1(2013):2005-2005.