Development of antibody therapeutics for small cell lung cancer

	Development of antibody therapeutics for small cell lung cancer
	Zhan, JB; Han, Q; Wang, KY
刊名	EXPERT OPINION ON INVESTIGATIONAL DRUGS
	2013
卷号	22 期号:2 页码:235-244
关键词	monoclonal antibody antibody conjugate antibody therapeutics immunotherapy lung cancer small cell lung cancer targeted therapy
通讯作者	Zhan, JB (reprint author), Zhejiang Univ, Sch Med, Dept Biochem, Lab Gene & Antibody Engn, Hangzhou 310058, Zhejiang, Peoples R China.,jzhan2k@zju.edu.cn
英文摘要	Introduction: Small cell lung cancer (SCLC) is one of most aggressive cancers and only modest improvements have been achieved in overall survival over last 30 years. In recent years, antibody therapeutics has been actively studied and shown promise in treatment of SCLC. Areas covered: A comprehensive literature search through Medline and the registry database of clinical trials (ClinicalTrials.gov) was performed to collect all relevant preclinical and clinical data. The diverse antibody therapeutics which target against different antigens including VEGE-A, CEA, IGF-1R, CD56, EpCAM, CTLA-4, gangliosides GD2 and GD3, Lewis Y and tenascin-C are now under clinical investigation for therapeutic effects in SCLC. Expert opinion: During the last few decades, progresses have been made in antibody therapy for SCLC, however great challenges still remain. The major reasons are the complexity of SCLC and a lack of understanding of cancer immunology. The profound studies of signaling pathways involved in carcinogenesis, proliferation, metastasis and apoptosis in SCLC are crucial for the identification of new therapeutic targets and biomarkers. Moreover, a better understanding of the interplay between cancer and the immune system is a new direction for the design of more effective antibody therapeutics.
学科主题	Pharmacology & Pharmacy
类目[WOS]	Pharmacology & Pharmacy
关键词[WOS]	HUMANIZED MONOCLONAL-ANTIBODY ; CARCINOEMBRYONIC ANTIGEN CEA ; PHASE-III TRIAL ; COMBINATION CHEMOTHERAPY ; ADJUVANT VACCINATION ; RESPONDING PATIENTS ; RANDOMIZED-TRIAL ; BREAST-CANCER ; CARCINOMA ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000313592000006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/343]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhan, JB,Han, Q,Wang, KY. Development of antibody therapeutics for small cell lung cancer[J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS,2013,22(2):235-244.
APA	Zhan, JB,Han, Q,&Wang, KY.(2013).Development of antibody therapeutics for small cell lung cancer.EXPERT OPINION ON INVESTIGATIONAL DRUGS,22(2),235-244.
MLA	Zhan, JB,et al."Development of antibody therapeutics for small cell lung cancer".EXPERT OPINION ON INVESTIGATIONAL DRUGS 22.2(2013):235-244.