Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta

	Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta
	Jing, P; Zhang, JY; Ouyang, Q; Wu, J; Zhang, XJ
刊名	CHEMICO-BIOLOGICAL INTERACTIONS
	2013
卷号	203 期号:1 页码:309-313
关键词	Acetylcholinesterase (AChE) Glycogen synthase kinase-3 beta (GSK3 beta) HEK293T cells Proteasome
通讯作者	Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 YueYang Rd, Shanghai 200031, Peoples R China.,xjzhang@sibs.ac.cn
英文摘要	Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder. Lithium is also a potent inhibitor of glycogen synthase kinase-3 beta (GSK3 beta) activity, which is linked to Alzheimer's disease (AD). In experiments with cultured HEK293T cells, we show here that GSK3 beta stabilizes synaptic acetylcholinesterase (AChE-S), a critical component of AD development. Cells treated with lithium exhibited rapid proteasomal degradation of AChE-S. Furthermore treatment of the cells with MG 132, an inhibitor of the 265 proteasome, prevented the destabilizing effect of lithium on AChE-S. Taken together, these findings suggest that regulation of AChE-S protein stability may be an important biological target of lithium therapy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
类目[WOS]	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Toxicology
关键词[WOS]	GLYCOGEN-SYNTHASE KINASE-3 ; ALZHEIMERS-DISEASE ; INDUCED APOPTOSIS ; N-GLYCOSYLATION ; PROTEIN-KINASE ; PHOSPHORYLATION ; CELLS ; CHOLINESTERASES ; SIALYLATION ; INDUCTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000318201800061
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/314]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Jing, P,Zhang, JY,Ouyang, Q,et al. Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2013,203(1):309-313.
APA	Jing, P,Zhang, JY,Ouyang, Q,Wu, J,&Zhang, XJ.(2013).Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta.CHEMICO-BIOLOGICAL INTERACTIONS,203(1),309-313.
MLA	Jing, P,et al."Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3 beta".CHEMICO-BIOLOGICAL INTERACTIONS 203.1(2013):309-313.