Bone Marrow Transplantation Concurrently Reconstitutes Donor Liver and Immune System across Host Species Barrier in Mice

	Bone Marrow Transplantation Concurrently Reconstitutes Donor Liver and Immune System across Host Species Barrier in Mice
	Qi, ZP; Li, L; Wang, XF; Gao, X; Wang, X; Wei, HM; Zhang, J; Sun, R; Tian, ZG
刊名	PLOS ONE
	2014
卷号	9 期号:9 页码:e106791-e106791
通讯作者	Tian, ZG (reprint author), Univ Sci & Technol China, Sch Life Sci, Dept Immunol, Hefei 230026, Anhui, Peoples R China.,tzg@ustc.edu.cn
英文摘要	Liver immunopathologic mechanisms during hepatotropic infection, malignant transformation, and autoimmunity are still unclear. Establishing a chimeric mouse with a reconstituted liver and immune system derived from a single donor across species is critical to study regional donor immune responses in recipient liver. Using a strain of mice deficient in tyrosine catabolic enzyme fumarylacetoacetate hydrolase (fah(-/-)) and bone marrow transplantation (BMT), we reconstituted the donor's hepatocytes and immune cells across host species barrier. Syngeneic, allogeneic or even xenogeneic rat BMT rescued most recipient fah(-/-) mice against liver failure by donor BM-derived FAH(+) hepatocytes. Importantly, immune system developed normally in chimeras, and the immune cells together with organ architecture were intact and functional. Thus, donor BM can across host species barrier and concurrently reconstitutes MHC-identical response between immune cells and hepatocytes, giving rise to a new simple and convenient small animal model to study donor's liver immune response in mice.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	HEPATITIS-B-VIRUS ; HEMATOPOIETIC STEM-CELLS ; HUMANIZED MOUSE MODELS ; CORD BLOOD ; HUMAN HEPATOCYTES ; IN-VIVO ; MYELOMONOCYTIC CELLS ; XENOGENEIC GVHD ; TRANSGENIC MICE ; CD34(+) CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000347993600061
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/219]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Qi, ZP,Li, L,Wang, XF,et al. Bone Marrow Transplantation Concurrently Reconstitutes Donor Liver and Immune System across Host Species Barrier in Mice[J]. PLOS ONE,2014,9(9):e106791-e106791.
APA	Qi, ZP.,Li, L.,Wang, XF.,Gao, X.,Wang, X.,...&Tian, ZG.(2014).Bone Marrow Transplantation Concurrently Reconstitutes Donor Liver and Immune System across Host Species Barrier in Mice.PLOS ONE,9(9),e106791-e106791.
MLA	Qi, ZP,et al."Bone Marrow Transplantation Concurrently Reconstitutes Donor Liver and Immune System across Host Species Barrier in Mice".PLOS ONE 9.9(2014):e106791-e106791.