The Mediator complex: a master coordinator of transcription and cell lineage development

	The Mediator complex: a master coordinator of transcription and cell lineage development
	Yin, JW; Wang, G
刊名	DEVELOPMENT
	2014
卷号	141 期号:5 页码:977-987
关键词	Mediator complex Transcription Cell fate Lineage development Disease
通讯作者	Wang, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,gwang@sibcb.ac.cn
英文摘要	Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase II. Multiple subunits of the complex show specificity in relaying information from signals and transcription factors to the RNA polymerase II machinery, thus enabling control of the expression of specific genes. Recent studies have also provided novel mechanistic insights into the roles of Mediator in epigenetic regulation, transcriptional elongation, termination, mRNA processing, noncoding RNA activation and super enhancer formation. Based on these specific roles in gene regulation, Mediator has emerged as a master coordinator of development and cell lineage determination. Here, we describe the most recent advances in understanding the mechanisms of Mediator function, with an emphasis on its role during development and disease.
学科主题	Developmental Biology
类目[WOS]	Developmental Biology
关键词[WOS]	RNA-POLYMERASE-II ; PROLIFERATOR-ACTIVATED RECEPTOR ; THYROID-HORMONE RECEPTOR ; SMOOTH-MUSCLE-CELL ; GENE-EXPRESSION ; BINDING PROTEIN ; COACTIVATOR COMPLEX ; NUCLEAR RECEPTORS ; MAMMALIAN MEDIATOR ; DIRECT CONVERSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000331880900001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/193]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yin, JW,Wang, G. The Mediator complex: a master coordinator of transcription and cell lineage development[J]. DEVELOPMENT,2014,141(5):977-987.
APA	Yin, JW,&Wang, G.(2014).The Mediator complex: a master coordinator of transcription and cell lineage development.DEVELOPMENT,141(5),977-987.
MLA	Yin, JW,et al."The Mediator complex: a master coordinator of transcription and cell lineage development".DEVELOPMENT 141.5(2014):977-987.