Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60

	Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60
	Xiao, Y; Nagai, Y; Deng, GP; Ohtani, T; Zhu, ZQ; Zhou, ZC; Zhang, HT; Ji, MQ; Lough, JW; Samanta, A
刊名	CELL REPORTS
	2014
卷号	7 期号:5 页码:1471-1480
通讯作者	Greene, MI (reprint author), Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.,greene@reo.med.upenn.edu
英文摘要	The human FOXP3 molecule is an oligomeric transcriptional factor able to mediate activities that characterize T regulatory cells, a class of lymphocytes central to the regulation of immune responses. The activity of FOXP3 is regulated at the posttranslational level, in part by two histone acetyltransferases (HATs): TIP60 and p300. TIP60 and p300 work cooperatively to regulate FOXP3 activity. Initially, p300 and TIP60 interactions lead to the activation of TIP60 and facilitate acetylation of K327 of TIP60, which functions as a molecular switch to allow TIP60 to change binding partners. Subsequently, p300 is released from this complex, and TIP60 interacts with and acetylates FOXP3. Maximal induction of FOXP3 activities is observed when both p300 and TIP60 are able to undergo cooperative interactions. Conditional knockout of TIP60 in Treg cells significantly decreases the Treg population in the peripheral immune organs, leading to a scurfy-like fatal autoimmune disease.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	ACETYLTRANSFERASE ACTIVITY ; HISTONE ACETYLTRANSFERASE ; T-CELLS ; ACETYLATION ; TRANSCRIPTION ; AUTOACETYLATION ; DEACETYLASES ; INHIBITION ; APOPTOSIS ; PROMOTES
收录类别	SCI
语种	英语
WOS记录号	WOS:000338324200015
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/187]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xiao, Y,Nagai, Y,Deng, GP,et al. Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60[J]. CELL REPORTS,2014,7(5):1471-1480.
APA	Xiao, Y.,Nagai, Y.,Deng, GP.,Ohtani, T.,Zhu, ZQ.,...&Greene, MI.(2014).Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60.CELL REPORTS,7(5),1471-1480.
MLA	Xiao, Y,et al."Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60".CELL REPORTS 7.5(2014):1471-1480.