A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

	A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
	Jiao, S; Wang, HZ; Shi, ZB; Dong, AM; Zhang, WJ; Song, XM; He, F; Wang, YC; Zhang, ZZ; Wang, WJ
刊名	CANCER CELL
	2014
卷号	25 期号:2 页码:166-180
通讯作者	Ji, HB (reprint author), Chinese Acad Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Cell Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,hbji@sibcb.ac.cn ; rayzhang@sibcb.ac.cn ; zczhou@sibcb.ac.cn
英文摘要	The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4's tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers.
学科主题	Oncology; Cell Biology
类目[WOS]	Oncology ; Cell Biology
关键词[WOS]	HIPPO SIGNALING PATHWAY ; YES-ASSOCIATED PROTEIN ; ORGAN SIZE CONTROL ; CELL CONTACT INHIBITION ; GENE-EXPRESSION ; DROSOPHILA HOMOLOG ; TEAD/TEF FAMILY ; DOWN-REGULATION ; GROWTH-CONTROL ; CARCINOMA
收录类别	SCI
语种	英语
WOS记录号	WOS:000331498000006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/145]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Jiao, S,Wang, HZ,Shi, ZB,et al. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer[J]. CANCER CELL,2014,25(2):166-180.
APA	Jiao, S.,Wang, HZ.,Shi, ZB.,Dong, AM.,Zhang, WJ.,...&Zhou, ZC.(2014).A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer.CANCER CELL,25(2),166-180.
MLA	Jiao, S,et al."A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer".CANCER CELL 25.2(2014):166-180.