Distinct Chemokine Signaling Regulates lntegrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing

	Distinct Chemokine Signaling Regulates lntegrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing
	Sun, H; Liu, J; Zheng, YJ; Pan, YD; Zhang, K; Chen, JF
刊名	DEVELOPMENTAL CELL
	2014
卷号	30 期号:1 页码:61-70
通讯作者	Chen, JF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,jfchen@sibcb.ac.cn
英文摘要	Immune surveillance and host defense depend on the precisely regulated trafficking of lymphocytes. Integrin alpha(4)beta(7) mediates lymphocyte homing to the gut through its interaction with mucosa' vascular address in cell adhesion molecule-1 (MAdCAM-1). alpha(4)beta(7) also binds vascular cell adhesion molecule-1 (VCAM-1), which is expressed in other tissues. To maintain the tissue specificity of lymphocyte homing, alpha(4)beta(7) must distinguish one ligand from the other. Here, we demonstrate that alpha(4)beta(7) is activated by different chemokines in a ligand-specific manner. CCL25 stimulation promotes alpha(4)beta(7)-mediated lymphocyte adhesion to MAdCAM-1 but suppresses adhesion to VCAM-1, whereas CXCL10 stimulation has the opposite effect. Using separate pathways, CCL25 and CXCL10 stimulate differential phosphorylation states of the beta(7) tail and distinct talin and kindlin-3 binding patterns, resulting in different binding affinities of MAdCAM-1 and VCAM-1 to alpha(4)beta(7). Thus, our findings provide a mechanism for lymphocyte traffic control through the unique ligand-specific regulation of integrin adhesion by different chemokines.
学科主题	Cell Biology ; Developmental Biology
类目[WOS]	Cell Biology ; Developmental Biology
关键词[WOS]	INTEGRIN ACTIVATION ; T-CELLS ; MIGRATION ; EXPRESSION ; BINDING ; KINDLIN-3 ; AFFINITY ; ROLES ; LFA-1 ; NODES
收录类别	SCI
语种	英语
WOS记录号	WOS:000339307400010
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/121]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, H,Liu, J,Zheng, YJ,et al. Distinct Chemokine Signaling Regulates lntegrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing[J]. DEVELOPMENTAL CELL,2014,30(1):61-70.
APA	Sun, H,Liu, J,Zheng, YJ,Pan, YD,Zhang, K,&Chen, JF.(2014).Distinct Chemokine Signaling Regulates lntegrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing.DEVELOPMENTAL CELL,30(1),61-70.
MLA	Sun, H,et al."Distinct Chemokine Signaling Regulates lntegrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing".DEVELOPMENTAL CELL 30.1(2014):61-70.