Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency

	Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency
	Tan, FZ; Qian, C; Tang, K; Abd-Allah, SM; Jing, NH
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2015
卷号	290 期号:7 页码:4500-4511
通讯作者	Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,njing@sibcb.ac.cn
英文摘要	Mouse pluripotent stem cells (PSCs), such as ES cells and induced PSCs (iPSCs), are an excellent system to investigate the molecular and cellular mechanisms involved in early embryonic development. The signaling pathways orchestrated by leukemia inhibitor factor/STAT3, Wnt/beta-catenin, and FGF/MEK/ERK play key roles in the generation of pluripotency. However, the function of TGF-beta signaling in this process remains elusive. Here we show that inhibiting TGF-beta signaling with its inhibitor SB431542 can substitute for Oct4 during reprogramming. Moreover, inhibiting TGF-beta signaling can sustain the pluripotency of iPSCs and ES cells through modulating FGF/MEK/ERK signaling. Therefore, this study reveals a novel function of TGF-beta signaling inhibition in the generation and maintenance of PSCs.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	EMBRYONIC STEM-CELLS ; MOUSE SOMATIC-CELLS ; GROUND-STATE PLURIPOTENCY ; SMALL-MOLECULE COMPOUNDS ; EXTRACELLULAR-MATRIX ; PRIMITIVE ENDODERM ; HUMAN FIBROBLASTS ; DEFINED FACTORS ; SELF-RENEWAL ; DIFFERENTIATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000349458400055
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/84]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Tan, FZ,Qian, C,Tang, K,et al. Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(7):4500-4511.
APA	Tan, FZ,Qian, C,Tang, K,Abd-Allah, SM,&Jing, NH.(2015).Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency.JOURNAL OF BIOLOGICAL CHEMISTRY,290(7),4500-4511.
MLA	Tan, FZ,et al."Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency".JOURNAL OF BIOLOGICAL CHEMISTRY 290.7(2015):4500-4511.