A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes

	A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes
	Chen, L; Chu, C; Kong, XY; Huang, GH; Huang, T; Cai, YD
刊名	PLOS ONE
	2015
卷号	10 期号:3 页码:e0117090-e0117090
通讯作者	Huang, T (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China.,tohuangtao@126.com ; cai_yud@126.com
英文摘要	Uncovering the molecular mechanisms underlying reproduction is of great importance to infertility treatment and to the generation of healthy offspring. In this study, we discovered novel reproduction-related genes with a hybrid computational method, integrating three different types of method, which offered new clues for further reproduction research. This method was first executed on a weighted graph, constructed based on known protein-protein interactions, to search the shortest paths connecting any two known reproduction-related genes. Genes occurring in these paths were deemed to have a special relationship with reproduction. These newly discovered genes were filtered with a randomization test. Then, the remaining genes were further selected according to their associations with known reproduction-related genes measured by protein-protein interaction score and alignment score obtained by BLAST. The in-depth analysis of the high confidence novel reproduction genes revealed hidden mechanisms of reproduction and provided guidelines for further experimental validations.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	GENOME-WIDE ASSOCIATION ; CANDIDATE DISEASE GENES ; MITOTIC CELL-DIVISION ; HOLT-ORAM-SYNDROME ; TGF-BETA ; EMBRYONIC-DEVELOPMENT ; MALE-INFERTILITY ; GERM-CELL ; HETEROGENEOUS NETWORK ; MOUSE SPERMATOGENESIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000351277500014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/28]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, L,Chu, C,Kong, XY,et al. A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes[J]. PLOS ONE,2015,10(3):e0117090-e0117090.
APA	Chen, L,Chu, C,Kong, XY,Huang, GH,Huang, T,&Cai, YD.(2015).A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes.PLOS ONE,10(3),e0117090-e0117090.
MLA	Chen, L,et al."A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes".PLOS ONE 10.3(2015):e0117090-e0117090.