Opioid receptor trafficking and interaction in nociceptors

	Opioid receptor trafficking and interaction in nociceptors
	Zhang, X; Bao, L; Li, S
刊名	BRITISH JOURNAL OF PHARMACOLOGY
	2015
卷号	172 期号:2 页码:364-374
关键词	-opioid receptor -opioid receptor nociceptor dorsal root ganglion receptor trafficking receptor interaction morphine antinociceptive tolerance
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	Opiate analgesics such as morphine are often used for pain therapy. However, antinociceptive tolerance and dependence may develop with long-term use of these drugs. It was found that -opioid receptors can interact with -opioid receptors, and morphine antinociceptive tolerance can be reduced by blocking -opioid receptors. Recent studies have shown that - and -opioid receptors are co-expressed in a considerable number of small neurons in the dorsal root ganglion. The interaction of -opioid receptors with -opioid receptors in the nociceptive afferents is facilitated by the stimulus-induced cell-surface expression of -opioid receptors, and contributes to morphine tolerance. Further analysis of the molecular, cellular and neural circuit mechanisms that regulate the trafficking and interaction of opioid receptors and related signalling molecules in the pain pathway would help to elucidate the mechanism of opiate analgesia and improve pain therapy. Linked ArticlesThis article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit
学科主题	Pharmacology & Pharmacy
类目[WOS]	Pharmacology & Pharmacy
关键词[WOS]	DORSAL-ROOT GANGLIA ; PROTEIN-COUPLED RECEPTORS ; DENSE-CORE VESICLES ; SUBSTANCE-P RELEASE ; SPINAL-CORD ; MORPHINE-TOLERANCE ; SENSORY NEURONS ; MESSENGER-RNAS ; KNOCKOUT MICE ; MU-RECEPTOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000346826500013
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/26]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, X,Bao, L,Li, S. Opioid receptor trafficking and interaction in nociceptors[J]. BRITISH JOURNAL OF PHARMACOLOGY,2015,172(2):364-374.
APA	Zhang, X,Bao, L,&Li, S.(2015).Opioid receptor trafficking and interaction in nociceptors.BRITISH JOURNAL OF PHARMACOLOGY,172(2),364-374.
MLA	Zhang, X,et al."Opioid receptor trafficking and interaction in nociceptors".BRITISH JOURNAL OF PHARMACOLOGY 172.2(2015):364-374.