Thermally and Magnetically Dual- Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Thermally and Magnetically Dual- Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine
	Dong, Liling 1; Peng, Hailong 1,2; Wang, Shenqi 1; Zhang, Zhong 3; Li, Jinhua3 ; Ai, Fanrong 4; Zhao, Qiang 1; Luo, Mei 1,2; Xiong, Hua 1; Chen, Lingxin3
刊名	JOURNAL OF APPLIED POLYMER SCIENCE
	2014-07-05
卷号	131 期号:13 页码:40477
关键词	biocompatibility biomedical applications functionalization of polymers drug-delivery systems stimuli-sensitive polymers
ISSN号	0021-8995
通讯作者	Xiong, H (reprint author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China. huaxiong100@126.com ; lxchen@yic.ac.cn
产权排序	[Dong, Liling; Peng, Hailong; Wang, Shenqi; Zhao, Qiang; Luo, Mei; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong; Luo, Mei] Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China; [Zhang, Zhong; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China; [Ai, Fanrong] Nanchang Univ, Dept Mech Engn, Nanchang 330031, Peoples R China
中文摘要	Novel thermally and magnetically dual-responsive mesoporous silica nanoparticles [magnetic mesoporous silica nanospheres (M-MSNs)-poly(N-isopropyl acrylamide) (PNIPAAm)] were developed with magnetic iron oxide (Fe3O4) nanoparticles as the core, mesoporous silica nanoparticles as the sandwiched layer, and thermally responsive polymers (PNIPAAm) as the outer shell. M-MSN-PNIPAAm was initially used to control the release of sophoridine. The characteristics of M-MSN-PNIPAAm were investigated by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry, N-2 adsorption-desorption isotherms, and vibrating specimen magnetometry analyses. The results indicate that the Fe3O4 nanoparticles were incorporated into the M-MSNs, and PNIPAAm was grafted onto the surface of the M-MSNs via precipitation polymerization. The obtained M-MSN-PNIPAAm possessed superparamagnetic characteristics with a high surface area (292.44 m(2)/g), large pore volume (0.246 mL/g), and large mesoporous pore size (2.18 nm). Sophoridine was used as a drug model to investigate the loading and release properties at different temperatures. The results demonstrate that the PNIPAAm layers on the surface of M-MSN-PNIPAAm effectively regulated the uptake and release of sophoridine. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40477.
英文摘要	Novel thermally and magnetically dual-responsive mesoporous silica nanoparticles [magnetic mesoporous silica nanospheres (M-MSNs)-poly(N-isopropyl acrylamide) (PNIPAAm)] were developed with magnetic iron oxide (Fe3O4) nanoparticles as the core, mesoporous silica nanoparticles as the sandwiched layer, and thermally responsive polymers (PNIPAAm) as the outer shell. M-MSN-PNIPAAm was initially used to control the release of sophoridine. The characteristics of M-MSN-PNIPAAm were investigated by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry, N-2 adsorption-desorption isotherms, and vibrating specimen magnetometry analyses. The results indicate that the Fe3O4 nanoparticles were incorporated into the M-MSNs, and PNIPAAm was grafted onto the surface of the M-MSNs via precipitation polymerization. The obtained M-MSN-PNIPAAm possessed superparamagnetic characteristics with a high surface area (292.44 m(2)/g), large pore volume (0.246 mL/g), and large mesoporous pore size (2.18 nm). Sophoridine was used as a drug model to investigate the loading and release properties at different temperatures. The results demonstrate that the PNIPAAm layers on the surface of M-MSN-PNIPAAm effectively regulated the uptake and release of sophoridine. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40477.
学科主题	Polymer Science
研究领域[WOS]	Polymer Science
关键词[WOS]	DRUG-DELIVERY SYSTEM ; CHITOSAN MICROSPHERES ; NANOPARTICLES ; CORE ; COPOLYMER ; HYDROGELS ; CARRIER ; SMART
收录类别	SCI
语种	英语
WOS记录号	WOS:000334600500063
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/8727]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China 2.Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China 4.Nanchang Univ, Dept Mech Engn, Nanchang 330031, Peoples R China
推荐引用方式 GB/T 7714	Dong, Liling,Peng, Hailong,Wang, Shenqi,et al. Thermally and Magnetically Dual- Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2014,131(13):40477.
APA	Dong, Liling.,Peng, Hailong.,Wang, Shenqi.,Zhang, Zhong.,Li, Jinhua.,...&Chen, Lingxin.(2014).Thermally and Magnetically Dual- Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine.JOURNAL OF APPLIED POLYMER SCIENCE,131(13),40477.
MLA	Dong, Liling,et al."Thermally and Magnetically Dual- Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine".JOURNAL OF APPLIED POLYMER SCIENCE 131.13(2014):40477.