Altered brain functional networks in heavy smokers

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Altered brain functional networks in heavy smokers
	Lin, Fuchun 1; Wu, Guangyao 2; Zhu, Ling 2; Lei, Hao 1
刊名	ADDICTION BIOLOGY
	2015-07-01
卷号	20 期号:4 页码:809-819
关键词	Functional networks heavy smokers network efficiency resting-state fMRI small-world
英文摘要	Recent neuroimaging studies have demonstrated that cigarette smoking is associated with changed brain structure and function. However, little is known about alterations of the topological organization of brain functional networks in heavy smokers. Thirty-one heavy smokers and 33 non-smokers underwent a resting-state functional magnetic resonance imaging scan. The whole-brain functional networks were constructed by thresholding the correlation matrices of 90 brain regions and their topological properties were analyzed using graph network analysis. Non-parametric permutation tests were performed to investigate group differences in network topological measures and multiple regression analysis was conducted to determine the relationships between the network metrics and smoking-related variables. Both heavy smokers and non-smokers exhibited small-world architecture in their brain functional networks. Compared with non-smokers, however, heavy smokers showed altered topological measurements characterized by lower global efficiency, higher local efficiency and clustering coefficients and greater path length. Furthermore, heavy smokers demonstrated decreased nodal global efficiency mainly in brain regions within the default mode network, whereas increased nodal local efficiency predominated in the visual-related regions. In addition, heavy smokers exhibited an association between the altered network metrics and the duration of cigarette use or the severity of nicotine dependence. Our results suggest that heavy smokers may have less efficient network architecture in the brain, and chronic cigarette smoking is associated with disruptions in the topological organization of brain networks. Our findings may further the understanding of the effects of chronic cigarette smoking on the brain and the pathophysiological mechanisms underlying nicotine dependence.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]	Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]	SMALL-WORLD NETWORKS ; CHRONIC CIGARETTE SMOKERS ; GRAY-MATTER VOLUMES ; MICROSTRUCTURAL INTEGRITY ; STRUCTURAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; COGNITIVE DECLINE ; DEFAULT MODE ; WHITE-MATTER ; RISK-FACTOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000355989600016
公开日期	2015-07-28
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4758]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Wuhan Univ, Dept Magnet Resonance Imaging, Zhongnan Hosp, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Lin, Fuchun,Wu, Guangyao,Zhu, Ling,et al. Altered brain functional networks in heavy smokers[J]. ADDICTION BIOLOGY,2015,20(4):809-819.
APA	Lin, Fuchun,Wu, Guangyao,Zhu, Ling,&Lei, Hao.(2015).Altered brain functional networks in heavy smokers.ADDICTION BIOLOGY,20(4),809-819.
MLA	Lin, Fuchun,et al."Altered brain functional networks in heavy smokers".ADDICTION BIOLOGY 20.4(2015):809-819.