The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice
	Niu, Haichen 1; Zheng, Yingwei 2,3; Rizak, Joshua D.3; Fan, Yaodong 4; Huang, Wei 1; Ma, Yuanye 2,3; Lei, Hao 1
刊名	BEHAVIOURAL BRAIN RESEARCH
	2012-07-15
卷号	233 期号:1 页码:71-78
关键词	Lesion of the olfactory epithelium Morphine Sensitization Conditioned place preference FosB-like protein ZnSO4 effusion
英文摘要	Animals attain information about their environment through different sense organs. For example, the dominant external resource about the environment for rodents is obtained through olfaction. Many environmental conditions (stress or enriched environment) are known to affect an animal's susceptibility to drug addiction. However, it is not known how external information is integrated and paired with drug stimuli to develop into addictive behavior. Here, we investigated the effects of olfactory epithelium lesions induced with ZnSO4 effusion (ZnE) on morphine-induced sensitization and conditioned place preference in mice. We found that the lesion of the olfactory epithelium attenuated the repeated morphine (40 mg/kg)-induced behavioral sensitization and morphine-induced conditioned place preference (CPP) behaviors, such as hyper-locomotion during morphine (40 mg/kg) conditioned training. Additionally, the expression of FosB-like proteins, transcription factors associated with behavioral alterations, in the nucleus accumbens of the brain was attenuated in morphine administered mice treated by ZnE. Taken together, these results indicated that lesion of the olfactory epithelium lead to a decrease in morphine sensitization and CPP behavior in mice as well as modulate specific molecular markers of neuroadaption to drugs of abuse. These findings also suggest that olfaction plays an important role in the development of addictive behaviors that can be modulated by external actions. (C) 2012 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	NUCLEUS-ACCUMBENS ; DELTA-FOSB ; BEHAVIORAL SENSITIZATION ; REWARD ; AMPHETAMINE ; ADDICTION ; DOPAMINE ; MEMORY ; ENVIRONMENT ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000306209500009
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1685]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Yunnan Key Lab Primate Biomed Res, Kunming 650051, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 4.Yunnan Prov Tumor Hosp, Dept Neurosurg, Kunming 650106, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Niu, Haichen,Zheng, Yingwei,Rizak, Joshua D.,et al. The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice[J]. BEHAVIOURAL BRAIN RESEARCH,2012,233(1):71-78.
APA	Niu, Haichen.,Zheng, Yingwei.,Rizak, Joshua D..,Fan, Yaodong.,Huang, Wei.,...&Lei, Hao.(2012).The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice.BEHAVIOURAL BRAIN RESEARCH,233(1),71-78.
MLA	Niu, Haichen,et al."The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice".BEHAVIOURAL BRAIN RESEARCH 233.1(2012):71-78.