Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats-a comparative study with diffusion tensor imaging and morphological analysis

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats-a comparative study with diffusion tensor imaging and morphological analysis
	Li, Shangxun 1; Sun, Yan 2; Shan, Dai 3; Feng, Bin 2; Xing, Jingjun 1; Duan, Yijie 1; Dai, Jiapei 2; Lei, Hao 3; Zhou, Yiwu 1
刊名	INTERNATIONAL JOURNAL OF LEGAL MEDICINE
	2013
卷号	127 期号:1 页码:159-167
关键词	Traumatic brain injury Traumatic axonal injury Diffusion tensor imaging Biomarker beta-Amyloid precursor protein Neurofilament
英文摘要	Traumatic axonal injury (TAI) plays a major role in the development of neurological impairments after traumatic brain injury (TBI), but it is commonly difficult to evaluate it precisely and early with conventional histological biomarkers, especially when the patients experience short-term survival after TBI. Diffusion tensor imaging (DTI) has shown some promise in detecting TAI, but longitudinal studies on the compromised white matter with DTI at early time points (a parts per thousand currency sign72 h) following impact acceleration TBI are still absent. In the present study, rats were subjected to the Marmarou model and imaged with DTI at 3, 12, 24, and 72 h (n = 5 each) post-injury. Using a region-of-interest-based approach, the regions of interest including the corpus callosum, bilateral external capsule, internal capsule, and pyramidal tract were studied. Two DTI parameters, fraction anisotropy and axial diffusivity, were significantly reduced from 3 to 72 h in each region after trauma, corresponding to the gradient of axonal damage demonstrated by immunohistochemical staining of beta-amyloid precursor protein and neurofilament light chain. Remarkably, DTI changes predicted the approximate time in the acute phase following TBI. These results indicate that the temporal profiles of diffusion parameters in DTI may be able to provide a tool for early diagnosis of TAI following impact acceleration TBI.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Medicine, Legal
研究领域[WOS]	Legal Medicine
关键词[WOS]	INTRAAXONAL NEUROFILAMENT COMPACTION ; AMYLOID PRECURSOR PROTEIN ; HEAD-INJURY ; SPINAL-CORD ; EARLY-DIAGNOSIS ; MOUSE MODEL ; DAMAGE ; ACCUMULATION ; TRANSPORT ; RECOVERY
收录类别	SCI
语种	英语
WOS记录号	WOS:000313164100023
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1029]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Fac Forens Med, Wuhan 430030, Peoples R China 2.S Cent Univ Nationlities, Wuhan Inst Neurosci & Neuroengn, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Li, Shangxun,Sun, Yan,Shan, Dai,et al. Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats-a comparative study with diffusion tensor imaging and morphological analysis[J]. INTERNATIONAL JOURNAL OF LEGAL MEDICINE,2013,127(1):159-167.
APA	Li, Shangxun.,Sun, Yan.,Shan, Dai.,Feng, Bin.,Xing, Jingjun.,...&Zhou, Yiwu.(2013).Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats-a comparative study with diffusion tensor imaging and morphological analysis.INTERNATIONAL JOURNAL OF LEGAL MEDICINE,127(1),159-167.
MLA	Li, Shangxun,et al."Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats-a comparative study with diffusion tensor imaging and morphological analysis".INTERNATIONAL JOURNAL OF LEGAL MEDICINE 127.1(2013):159-167.