New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization

	New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization
	Chen, Xiaoyu ; Lai, Haiwang ; Xiao, Chunsheng ; Tian,Huayu ; Chen,Xuesi ; Tao,Youhua ; Wang,Xianhong
刊名	polymer chemistry
	2014
卷号	5 期号:22 页码:6495-6502
关键词	POLY-L-LYSINE GENE DELIVERY MOLECULAR-WEIGHT CLICK CHEMISTRY PLASMID DNA ACID COPOLYMERS CARBOXYANHYDRIDES LACTIDE DRUG
通讯作者	tao,yh
英文摘要	lysine, a renewable resource from biomass fermentation, was simply converted to its corresponding a-hydroxyl acids and then cyclized to give the pure o-carboxyanhydride (oca) monomer. ring-opening polymerization of the resulting monomer was carried out using dimethylaminopyridine (dmap) as a catalyst in ch2cl2 at room temperature, and gave well-defined lysine-derived polyesters bearing pendant carbobenzyloxy (cbz)-protected amino groups with number average molecular weight of up to 45 kg mol(-1) in narrow polydispersity. h-1 nmr, gpc, and maldi-tof ms measurements of the products clearly indicated the controlled/living character of the polymerization. moreover, amino-functionalized polyesters were readily prepared by the removal of the cbz protecting group, and the integrity of the polyester backbone was confirmed by h-1 nmr. these amino-functionalized polyesters showed a tunable glass transition temperature and exhibited excellent cell compatibility, suggesting their potential to be used as novel materials in biomedical applications.
收录类别	SCI
语种	英语
WOS记录号	WOS:000343703900013
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/53010]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen, Xiaoyu,Lai, Haiwang,Xiao, Chunsheng,et al. New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization[J]. polymer chemistry,2014,5(22):6495-6502.
APA	Chen, Xiaoyu.,Lai, Haiwang.,Xiao, Chunsheng.,Tian,Huayu.,Chen,Xuesi.,...&Wang,Xianhong.(2014).New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization.polymer chemistry,5(22),6495-6502.
MLA	Chen, Xiaoyu,et al."New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization".polymer chemistry 5.22(2014):6495-6502.