Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy

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	Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy
	Li,Dongyan; Xue,Yongbo; Zhu,Hucheng; Li,Yan; Sun,Bin; Liu,Junjun; Yao,Guangmin; Zhang,Jinwen; Du,Guang; Zhang,Yonghui
刊名	RSC ADVANCES
	2015
卷号	5 期号:7 页码:5277-5287
通讯作者	Zhang,YH (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.
英文摘要	Nine new polyprenylated acylphloroglucinols (PPAPs), hyperattenins A-I (1-9), together with thirteen known analogues (10-22), were isolated from the aerial parts of Hypericum attenuatum Choisy. The structures of 1-9 were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by a single X-ray crystallographic analysis, and the absolute configurations of 2-9 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 was characterised as a bicyclo[3.3.1] nonane derivative containing an unusual hemiacetal functionality formed by a series of redox reactions on its side chains, which occurs rarely in nature. All new isolates were evaluated for cytotoxic activities against several human cancer cell lines. Compound 9 exhibited significant inhibitory activity against the HL-60 and A-549 cell lines, with IC50 values of 2.04 and 3.26 mu M, respectively. Compound 9 also showed low toxicity to Beas-2B cells (IC50 = 14.36 mu M), suggesting that it could be a selective anti-tumour agent for leukaemia and lung cancer. Compounds 2-8 were also screened for their anti-HIV-1 activities.
学科主题	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES ; SAMPSONII ; BENZOPHENONE ; PERFORATUM
收录类别	SCI
语种	英语
WOS记录号	WOS:000346733500077
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20563]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
推荐引用方式 GB/T 7714	Li,Dongyan,Xue,Yongbo,Zhu,Hucheng,et al. Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy[J]. RSC ADVANCES,2015,5(7):5277-5287.
APA	Li,Dongyan.,Xue,Yongbo.,Zhu,Hucheng.,Li,Yan.,Sun,Bin.,...&Zhang,Yonghui.(2015).Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy.RSC ADVANCES,5(7),5277-5287.
MLA	Li,Dongyan,et al."Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy".RSC ADVANCES 5.7(2015):5277-5287.