Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta | |
Jie, Xiao-Xia1,2,3; Geng, Chang-An3; Huang, Xiao-Yan3; Ma, Yun-Bao3; Zhang, Xue-Mei3; Zhang, Rong-Ping1,2; Chen, Ji-Jun3 | |
刊名 | FITOTERAPIA |
2015-04-01 | |
卷号 | 102页码:96-101 |
关键词 | Swertia cincta Secoiridoid glycosides Lactonic enol ketone Anti-HBV activity |
英文摘要 | Five new secoiridoid glycosides, swericinctosides A and B (1-2), 9-epi swertiamarin (3), 2'-O-m-hydroxybenzoyl swertiamarin (4), 4 ''-O-acetyl swertianoside E (5), and one unusual lactonic enol ketone, 3-(hydroxymethyl ene) dihydro-2H-pyran-2, 4(3H)-dione (6), together with three known compounds, swertiaside (7), swertianoside C (8) and decentapicrin B (9) were isolated from Swertia cincta. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, UV, IR and [alpha](D) spectra. Anti-HBV assay on HepG 22.15 cell line in vitro demonstrated that compounds 1-9 possessed inhibitory activity on HBV DNA replication with IC50 values from 0.05 to 1.83 mM, and compounds 1, 3, 5, 7 and 8 could inhibit the secretion of HBsAg with IC50 values from 024 to 1.06 mM. (C) 2015 Elsevier B.V. All rights reserved. |
类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
研究领域[WOS] | Pharmacology & Pharmacy |
关键词[WOS] | CHEMICAL-CONSTITUENTS ; MILEENSIS ; GENTIANACEAE ; ANGUSTIFOLIA ; JAPONICA |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000353742600014 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/20685] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China |
推荐引用方式 GB/T 7714 | Jie, Xiao-Xia,Geng, Chang-An,Huang, Xiao-Yan,et al. Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta[J]. FITOTERAPIA,2015,102:96-101. |
APA | Jie, Xiao-Xia.,Geng, Chang-An.,Huang, Xiao-Yan.,Ma, Yun-Bao.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2015).Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta.FITOTERAPIA,102,96-101. |
MLA | Jie, Xiao-Xia,et al."Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta".FITOTERAPIA 102(2015):96-101. |
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