Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity
	Luo, Qi1,3 ; Di, Lei 1; Dai, Wei-Feng 1,4; Lu, Qing 1; Yan, Yong-Ming 1,3; Yang, Zhu-Liang2 ; Li, Rong-Tao 4; Cheng, Yong-Xian 1
刊名	ORGANIC LETTERS
	2015-03-06
卷号	17 期号:5 页码:1110-1113
通讯作者	Cheng,YX (reprint author),Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; yxcheng@mail.kib.ac.cn
英文摘要	Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-beta 1-induced human renal proximal tubular cells.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	GROWTH-FACTOR-BETA ; MESENCHYMAL TRANSITION ; TGF-BETA ; FIBROSIS ; MECHANISMS ; INHIBITOR ; P-SMAD3
收录类别	SCI
语种	英语
WOS记录号	WOS:000350841300013
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20594]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
推荐引用方式 GB/T 7714	Luo, Qi,Di, Lei,Dai, Wei-Feng,et al. Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity[J]. ORGANIC LETTERS,2015,17(5):1110-1113.
APA	Luo, Qi.,Di, Lei.,Dai, Wei-Feng.,Lu, Qing.,Yan, Yong-Ming.,...&Cheng, Yong-Xian.(2015).Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity.ORGANIC LETTERS,17(5),1110-1113.
MLA	Luo, Qi,et al."Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity".ORGANIC LETTERS 17.5(2015):1110-1113.