Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo
	Cheng, Bao-Hui 1,2; Zhou, Xuelin 1,2; Wang, Yan 3; Chan, Judy Yuet-Wa 1,2; Lin, Huang-Quan 1,2; Or, Penelope M. Y.4; Wan, David Chi-Cheong 4; Leung, Ping-Chung 1,2; Fung, Kwok-Pui 1,2,4; Wang, Yi-Fen5
刊名	JOURNAL OF ETHNOPHARMACOLOGY
	2015-03-13
卷号	162 页码:369-376
关键词	SH formula Atazanavir Anti-HIV CYP3A2 Herb-drug interaction
通讯作者	Lau,CBS (reprint author),Chinese Univ Hong Kong,Inst Chinese Med,Shatin,Hong Kong,Peoples R China. ; claralau@cuhk.edu.hk
英文摘要	Ethnopharmacological relevance: With the prevalent use of highly active antiretroviral therapy (HAART) for AIDS patients since 1996, the mortality of HIV/AIDS patients has been remarkably decreased. With long-term use of HAART, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. Traditional herbal medicine has become more popular among HIV/AIDS patients as adjuvant therapy to reduce these adverse effects of HAART. SH formula is a Chinese herbal formula consisting of five traditional Chinese herbs including Morus alba L, Glycyrrhiza glabra L, Artemisia capillaris Thumb., Astragalus membranaceus Bge., and Carthamus tinctorius L. SH formula is clinically used for HIV treatment in Thailand. However, the possible pharmacokinetic interactions between these Chinese herbs and antiretroviral drugs have not been well documented. The aim of this study was to investigate the potential herb-drug interaction between SH herbal Chinese formula and the antiretroviral drug atazanavir (ATV).
学科主题	Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]	PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; PROTEASE ; METABOLISM ; CYP3A4 ; CYP2D6
收录类别	SCI
语种	英语
WOS记录号	WOS:000351323400047
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20581]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China 2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China 4.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Bao-Hui,Zhou, Xuelin,Wang, Yan,et al. Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,162:369-376.
APA	Cheng, Bao-Hui.,Zhou, Xuelin.,Wang, Yan.,Chan, Judy Yuet-Wa.,Lin, Huang-Quan.,...&Lau, Clara Bik-San.(2015).Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo.JOURNAL OF ETHNOPHARMACOLOGY,162,369-376.
MLA	Cheng, Bao-Hui,et al."Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo".JOURNAL OF ETHNOPHARMACOLOGY 162(2015):369-376.