Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks

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	Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks
	He, Xingu 1,2; Xiao, Lin 1; Sui, Nan1 ; Nan Sui
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2010-02-10
通讯作者邮箱	suin@psych.ac.cn
卷号	627 期号:1-3 页码:136-141
关键词	Morphine Conditioned place preference The medial striatum The intermediate medial mesopallium Reward-related learning Day-old chicks
ISSN号	0014-2999
通讯作者	Nan Sui
产权排序	1
合作状况	国内
中文摘要	.
英文摘要	In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various behavioral paradigms, such as one-trial passive avoidance learning. However, it is not yet clear whether the dopaminergic system of these regions is responsible for associative learning underlying cue-elicited drug reward. In this study, a 6-day conditioning schedule in day-old chicks with i.p. morphine (2 mg/kg) was used to compare the effects of intracerebrally injected dopamine D(1) receptor antagonist, SCH23390, and D(2) antagonist, spiperone. The antagonists were injected bilaterally (3 mu g/site) into either the medial striatum or the intermediate medial mesopallium, and tests were conducted on morphine-induced conditioned place preference or locomotor activity. The acquisition of place preference was significantly inhibited by SCH23390 in either the medial striatum or the intermediate medial mesopallium, but not by spiperone. However, in the medial striatum, but not in the intermediate medial mesopallium, the locomotor activity was blocked by both SCH23390 and spiperone. These data suggest that the medial striatum and the intermediate medial mesopallium in birds are differentially involved in the rewarding effects of morphine, and similarly to mammals, the dopamine D(1) system may play an important role in the development of opiate reward. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
学科主题	生理心理学/生物心理学
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000274093800020
公开日期	2014-06-10
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10077]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Nan Sui
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	He, Xingu,Xiao, Lin,Sui, Nan,et al. Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,627(1-3):136-141.
APA	He, Xingu,Xiao, Lin,Sui, Nan,&Nan Sui.(2010).Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks.EUROPEAN JOURNAL OF PHARMACOLOGY,627(1-3),136-141.
MLA	He, Xingu,et al."Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks".EUROPEAN JOURNAL OF PHARMACOLOGY 627.1-3(2010):136-141.