Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia

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	Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
	Zhang, Xiang Yang 1,2,3,4; Zhou, Dong Feng 1; Shen, Yu Cun 1; Zhang, Pei Yan 4; Zhang, Wu Fang 1; Liang, Jun 1; Chen, Da Chun 4; Xiu, Mei Hong 4; Kosten, Therese A.2; Kosten, Thomas R.2
刊名	NEUROPHARMACOLOGY
	2012-04-01
卷号	62 期号:5-6 页码:1928-1934
关键词	Schizophrenia Free radical Oxidative stress Antipsychotic treatment
ISSN号	0028-3908
通讯作者	Zhang, XY (reprint author), VA Med Ctr, Res Bldg 109,Room 130,2002 Holcombe Blvd, Houston, TX 77030 USA.
产权排序	3
英文摘要	Oxidative stress may be involved in the pathophysiology of schizophrenia. No double-blind study has compared the effects of typical and atypical antipsychotics on both antioxidant enzyme activity and nitric oxide (NO) levels in schizophrenic patients. Seventy-eight inpatients with chronic schizophrenia were randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol using a double-blind design. Clinical efficacy was determined using the Positive and Negative Syndrome Scale. Blood superoxide dismutase (SOD) and plasma NO levels were measured in patients and 30 normal controls. Our results showed that following a 2-week washout period, levels of SOD and NO were significantly increased in patients with schizophrenia compared to normal controls. Both risperidone and haloperidol equivalently reduced the elevated blood SOD levels in schizophrenia, but neither medication reduced the elevated plasma NO levels in schizophrenia. Low blood SOD levels at baseline predicted greater symptom improvement during treatment, and greater change in SOD was correlated with greater symptom improvement. These results suggest that both typical and atypical antipsychotic drugs may at least partially normalize abnormal free radical metabolism in schizophrenia, and some free radical parameters at baseline may predict antipsychotic responses of schizophrenic patients. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Abnormal psychology
收录类别	SCI
项目简介	This study was partially funded by the Stanley Medical Research Institute (03T-459 and 05T-726), the Beijing Municipal Natural Science Foundation (ID: 7072035), and the Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health K05-DA0454, P50-DA18827 and U01-MH79639.
原文出处	http://ac.els-cdn.com/S0028390811005181/1-s2.0-S0028390811005181-main.pdf?_tid=d5ef5ea8-add1-11e4-8b77-00000aab0f27&acdnat=1423207927_9f5ecc8096dc6e724ed5953a5b38790a
语种	英语
WOS记录号	WOS:000301474300003
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11488]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 4.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiang Yang,Zhou, Dong Feng,Shen, Yu Cun,et al. Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia[J]. NEUROPHARMACOLOGY,2012,62(5-6):1928-1934.
APA	Zhang, Xiang Yang.,Zhou, Dong Feng.,Shen, Yu Cun.,Zhang, Pei Yan.,Zhang, Wu Fang.,...&Kosten, Thomas R..(2012).Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia.NEUROPHARMACOLOGY,62(5-6),1928-1934.
MLA	Zhang, Xiang Yang,et al."Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia".NEUROPHARMACOLOGY 62.5-6(2012):1928-1934.