Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction

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	Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction
	Levran, Orna ; Peles, Einat ; Randesi, Matthew ; Shu, Xu ; Ott, Jurg ; Shen, Pei-Hong ; Adelson, Miriam ; Kreek, Mary Jeanne
刊名	PHARMACOGENOMICS
	2013
卷号	14 期号:7 页码:755-768
关键词	ANKK1 BDNF DRD2 methadone maintenance NTRK2 OPRM1 pharmacogenetics
ISSN号	0191-8869
通讯作者	Levran, O (reprint author), Rockefeller Univ, Lab Biol Addicit Dis, New York, NY 10021 USA.
产权排序	4
英文摘要	Aim: The interindividual variability in the dose required for effective methadone maintenance treatment (MMT) for opioid addiction may be influenced in part by genetic variations in genes encoding pharmacodynamic factors of methadone. This study was conducted to identify some of these variants. Materials & methods: This study focused on 11 genes encoding components of the opioidergic (OPRM1, POMC and ARRB2), the dopaminergic (ANKK1 and DRD2) and the glutamatergic pathways (GRIN1 and GRIN2A), as well as the neurotrophin system (NGFB, BDNF, NTRK1 and NTRK2). The study includes 227 Israeli patients undergoing stable MMT. Results: Out of the 110 variants analyzed, 12 SNPs (in BDNF, NTRK2, OPRM1, DRD2 and ANKK1) were associated with methadone dose (nominal p < 0.05). Of these SNPs, ANKK1 rs7118900 and DRD2 rs2283265 are known to affect gene expression. Logistic regression of five representative SNPs discriminated between individuals requiring a methadone dose of >120 mg/day and <120 mg/day (p = 0.019), and showed moderate sensitivity and specificity (AUC of 0.63 in receiver operating characteristic analysis). Conclusion: This data should stimulate further research on the potential influence and clinical significance of these variants on MMT. Original submitted 14 November 2012; Revision submitted 12 March 2013.
学科主题	Physiological psychology/Biological Psychology，Medical psychology
收录类别	SCI
项目简介	Funding was provided by P60-05130 from NIDA (MJ Kreek), grant # 8 UL1 TR000043 from the National Center fir Research Resources and the National Center for Advancing Translational Sciences, NIH (pilot award, O Levran) and the Adelson Medical Research Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject watt or materials discussed in the manuscript apart from those disclosed.
原文出处	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867202/pdf/nihms532598.pdf
语种	英语
WOS记录号	WOS:000318846100016
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11414]
专题	心理研究所_中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Levran, Orna,Peles, Einat,Randesi, Matthew,et al. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction[J]. PHARMACOGENOMICS,2013,14(7):755-768.
APA	Levran, Orna.,Peles, Einat.,Randesi, Matthew.,Shu, Xu.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2013).Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.PHARMACOGENOMICS,14(7),755-768.
MLA	Levran, Orna,et al."Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction".PHARMACOGENOMICS 14.7(2013):755-768.