Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

	Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents
	Wang, Li-Jun; Wang, Shuai-Yu; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Wang, Bao-Cheng; Luo, Jiao; Yang, Meng; Jin, Shui-Hua; Shi, Da-Yong
刊名	MARINE DRUGS
	2015-02-01
卷号	13 期号:2 页码:806-823
英文摘要	A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g-4i, 5h, 6d, 7a, 7b) showed potent activity against the tested five human cancer cell lines. Wound-healing assay demonstrated that compound 4g can be used as a potent compound for inactivating invasion and metastasis by inhibiting the migration of cancer cells. The structure-activity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs.
收录类别	SCI
语种	英语
WOS记录号	WOS:000350217500008
公开日期	2015-06-16
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/25392]
专题	海洋研究所_海洋生物技术研发中心
作者单位	Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Li-Jun,Wang, Shuai-Yu,Jiang, Bo,et al. Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents[J]. MARINE DRUGS,2015,13(2):806-823.
APA	Wang, Li-Jun.,Wang, Shuai-Yu.,Jiang, Bo.,Wu, Ning.,Li, Xiang-Qian.,...&Shi, Da-Yong.(2015).Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents.MARINE DRUGS,13(2),806-823.
MLA	Wang, Li-Jun,et al."Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents".MARINE DRUGS 13.2(2015):806-823.