Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling

	Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling
	Wu, Ning 1; Luo, Jiao 1; Jiang, Bo 1; Wang, Lijun 1; Wang, Shuaiyu 1; Wang, Changhui 2; Fu, Changqing 2; Li, Jian 2; Shi, Dayong 1
刊名	MARINE DRUGS
	2015-02-01
卷号	13 期号:2 页码:1010-1025
英文摘要	Bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a natural bromophenol compound derived from marine algae. Previous reports have shown that BDDPM possesses antimicrobial activity. In the present study, we found that BDDPM has cytotoxic activity on a wide range of tumor cells, including BEL-7402 cells (IC50 = 8.7 mu g/mL). Further studies have shown that prior to the onset of apoptosis, the BDDPM induces BEL-7402 cell detachment by decreasing the adherence of cells to the extracellular matrix (ECM). Detachment experiments have shown that the treatment of BEL-7402 cells with low concentrations of BDDPM (5.0 mu g/mL) significantly inhibits cell adhesion to fibronectin and collagen IV as well as cell migration and invasion. High doses of BDDPM (10.0 mu g/mL) completely inhibit the migration of BEL-7402 cells, and the expression level of MMPs (MMP-2 and MMP-9) is significantly decreased. Moreover, the expression of beta 1-integrin and focal adhesion kinase (FAK) is found to be down-regulated by BDDPM. This study suggests that BDDPM has a potential to be developed as a novel anticancer therapeutic agent due to its anti-metastatic activity and also indicates that BDDPM, which has a unique chemical structure, could serve as a lead compound for rational drug design and for future development of anticancer agents.
收录类别	SCI
语种	英语
WOS记录号	WOS:000350217500020
公开日期	2015-06-16
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/25389]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Med Univ, Affiliated Hosp, Qingdao 266070, Peoples R China
推荐引用方式 GB/T 7714	Wu, Ning,Luo, Jiao,Jiang, Bo,et al. Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling[J]. MARINE DRUGS,2015,13(2):1010-1025.
APA	Wu, Ning.,Luo, Jiao.,Jiang, Bo.,Wang, Lijun.,Wang, Shuaiyu.,...&Shi, Dayong.(2015).Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling.MARINE DRUGS,13(2),1010-1025.
MLA	Wu, Ning,et al."Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling".MARINE DRUGS 13.2(2015):1010-1025.