Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens
	Liu, Ya-Ping 1; Zhao, Yun-Li 1; Feng, Tao 1; Cheng, Gui-Guang 1,2; Zhang, Bao-Hong 3; Li, Yan1 ; Cai, Xiang-Hai1 ; Luo, Xiao-Dong1
刊名	JOURNAL OF NATURAL PRODUCTS
	2013-12-01
卷号	76 期号:12 页码:2322-2329
英文摘要	Eight new bisindole alkaloids, melosuavines A C (1-3), having an aspidosperma-scandine linkage, melosuavines D F (4-6), possessing an aspidosperma-aspidosperma skeleton, and melosuavines G and H (7 and 8) of the aspidosperma-venalatonine type, tenuicausine (9), and melodinine J (10) were isolated from the twigs and leaves of Melodinus suaveolens. The structures of 1-8 were elucidated by extensive spectroscopic methods, and compounds 9 and 10 were identified by comparison with data in the literature. The relative configuration 9 was determined from the ROESY spectrum, and some NMR signals were reassigned. Compounds 1, 2, 4-6, 8, and 10 exhibited low micromolar cytotoxicity against one or more of five human cancer cell lines.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	INDOLE ALKALOIDS ; VINCA ALKALOIDS ; VINBLASTINE ; SURVIVAL ; CULTURES
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000329331200020
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/19248]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Kunming Fengshanjian Pharmaceut Corp, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ya-Ping,Zhao, Yun-Li,Feng, Tao,et al. Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(12):2322-2329.
APA	Liu, Ya-Ping.,Zhao, Yun-Li.,Feng, Tao.,Cheng, Gui-Guang.,Zhang, Bao-Hong.,...&Luo, Xiao-Dong.(2013).Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens.JOURNAL OF NATURAL PRODUCTS,76(12),2322-2329.
MLA	Liu, Ya-Ping,et al."Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens".JOURNAL OF NATURAL PRODUCTS 76.12(2013):2322-2329.