Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice

	Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice
	Wei, Jianteng 1,2,3; Wang, Shuxian 4; Liu, Ge 5; Pei, Dong 1,2,3; Liu, Yongfeng 1,2,3; Liu, Yi 1,2,3; Di, Duolong 1,2,3
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2014-03-01
卷号	64 页码:1-5
关键词	Enteromoipha prolifera Polysaccharide Immune response Immune-related enzyme NF-kB
通讯作者	Di, DL (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.
英文摘要	The effects of polysaccharides from Enteromorpha prolifera (PEP) on cell-mediated immunity, humoral immunity and mononuclear phagocytic system function were evaluated to assess the immunomodulatory potential of these macromolecules. Relevant immunological mechanisms were verified by biochemical assays and western blot analysis. Results showed that PEP could induce splenocyte proliferation. In vivo experiments on Kunming mice confirmed that PEP could improve cell-mediated immunity, humoral immunity and mononuclear phagocytic system function. To illustrate the mechanism, we determined several immune-related enzymes in the thymus and spleen. The results indicated that PEP could enhance the activities of alkaline phosphatase, superoxide dismutase and lactate dehydrogenase. PEP could also increase the level of NF-kB. These results suggested that PEP exhibited potent immunomodulatory properties and could be used as a novel potential immunostimulant in food and pharmaceutical industries. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000334147300001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/24237]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Ctr Resource Chem & New Mat, Qingdao 266100, Peoples R China 4.Mariculture Inst Shandong Prov, Qingdao 266002, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wei, Jianteng,Wang, Shuxian,Liu, Ge,et al. Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,64:1-5.
APA	Wei, Jianteng.,Wang, Shuxian.,Liu, Ge.,Pei, Dong.,Liu, Yongfeng.,...&Di, Duolong.(2014).Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,64,1-5.
MLA	Wei, Jianteng,et al."Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 64(2014):1-5.