Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges | |
Cui, Jian Dong1,2,3; Jia, Shi Ru3 | |
刊名 | CRITICAL REVIEWS IN BIOTECHNOLOGY |
2015-03-01 | |
卷号 | 35期号:1页码:15-28 |
关键词 | Biocatalysis cross-linked enzyme aggregates enzyme immobilization improved strategies process optimization |
ISSN号 | 0738-8551 |
通讯作者 | Cui, JD (reprint author), Hebei Univ Sci & Technol, Coll Biosci & Bioengn, 70 YuHua East Rd, Shijiazhuang 050018, Peoples R China. |
英文摘要 | Cross-linked enzyme aggregate (CLEA) technology has been regarded as an effective carrier-free immobilization method. This method is very attractive due to its simplicity and robustness, as well as for the possibility of using the crude enzyme extract and the opportunity to co-immobilize multiple different enzymes. The resulting CLEAs generally exhibit high catalyst productivities, improved storage and operational stability and are easy to recycle. Nowadays, although the technology has been applied to various enzymes, some undesirable properties have limited its further application. To overcome these limitations, novel strategies have been developing in recent years. This mini-review focuses on process optimization, new improved strategies and the latest advances on CLEAs technology. |
学科主题 | Biotechnology & Applied Microbiology |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Biotechnology & Applied Microbiology |
研究领域[WOS] | Biotechnology & Applied Microbiology |
关键词[WOS] | PENICILLIN-G ACYLASE ; PHENYLALANINE AMMONIA-LYASE ; ENDOCRINE-DISRUPTING CHEMICALS ; BOVINE SERUM-ALBUMIN ; THERMOPHILIC ENZYMES ; STABLE BIOCATALYSTS ; INDUSTRIAL ENZYMES ; CARBOXYPEPTIDASE-A ; CANDIDA-ANTARCTICA ; MESOPOROUS SILICA |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000350017200002 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/13823] |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Hebei Univ Sci & Technol, Coll Biosci & Bioengn, Res Ctr Fermentat Engn Hebei, Shijiazhuang 050018, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China 3.Tianjin Univ Sci & Technol, Minist Educ, Key Lab Ind Microbiol, Tianjin, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Jian Dong,Jia, Shi Ru. Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2015,35(1):15-28. |
APA | Cui, Jian Dong,&Jia, Shi Ru.(2015).Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges.CRITICAL REVIEWS IN BIOTECHNOLOGY,35(1),15-28. |
MLA | Cui, Jian Dong,et al."Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges".CRITICAL REVIEWS IN BIOTECHNOLOGY 35.1(2015):15-28. |
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