Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro | |
Wang, Lianyan1; Cai, Mingming1,2; Liu, Yuan1,3; Yang, Tingyuan1; Zeng, Yejing1; Zhang, Yueling1; Li, Qiang1; Zhu, Baocheng2; Ma, Guanghui1 | |
刊名 | POWDER TECHNOLOGY |
2015-05-01 | |
卷号 | 275期号:MAY页码:77-84 |
关键词 | Hydrophobicity Paclitaxel Polymer microspheres Distribution Crystal morphology Antitumor activity |
ISSN号 | 0032-5910 |
通讯作者 | Wang, LY (reprint author), Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, POB 353, Beijing 100190, Peoples R China. |
英文摘要 | Water-insoluble drugs such as paclitaxel (PTX) face a huge challenge for clinical applications due to their low aqueous solubility. In this study, uniform-sized poly (DL-lactic acid) (PLA), poly(DL-lactic-co-glycolic acid) (PLGA) and poly( ethylene glycol-co-lactide add) (PELA) microspheres containing PTX were prepared by premix membrane emulsification technique integrated with solvent evaporation method. The different hydrophobicity of polymer led to different distribution and crystal morphology of PTX in microspheres, which further resulted in different loading and encapsulation efficiency, release profile in vitro and cytotoxicity. The PLGA microspheres showed the highest loading and encapsulation efficiency of PTX (5.15%, 70.46%), followed by PLA microspheres (4.33%, 6433%), together with PELA microspheres (3.35%, 56.68%). The results of PTX release profile in vitro suggested that PLGA and PELA microspheres achieved a more rapid release rate than PLA microspheres due to their hydrophilic property. The antitumor activity in vitro was also evaluated by Lewis Lung Cells (LLC). The PTX-PLGA microspheres exhibited excellent antitumor activity compared with PLA and PELA microspheres, even much better than Taxol. Therefore, the PLGA microspheres show great potential in application as delivery carriers for water-insoluble drugs, PTX and others. (C) 2015 Elsevier B.V. All rights reserved. |
学科主题 | Engineering |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Engineering, Chemical |
研究领域[WOS] | Engineering |
关键词[WOS] | MEMBRANE EMULSIFICATION TECHNIQUE ; SOLVENT EVAPORATION METHOD ; PLA MICROCAPSULES ; SIZE DISTRIBUTION ; NANOPARTICLES ; DELIVERY ; DRUG ; ENCAPSULATION ; CANCER ; FORMULATION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000351801300009 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/13775] |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Agr Univ Hebei, Coll Life Sci, Baoding 071001, Hebei, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Lianyan,Cai, Mingming,Liu, Yuan,et al. Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro[J]. POWDER TECHNOLOGY,2015,275(MAY):77-84. |
APA | Wang, Lianyan.,Cai, Mingming.,Liu, Yuan.,Yang, Tingyuan.,Zeng, Yejing.,...&Ma, Guanghui.(2015).Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro.POWDER TECHNOLOGY,275(MAY),77-84. |
MLA | Wang, Lianyan,et al."Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro".POWDER TECHNOLOGY 275.MAY(2015):77-84. |
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