Systematic studies of Pickering emulsions stabilized by uniform-sized PLGA particles: preparation and stabilization mechanism

CORC > 过程工程研究所 > 中国科学院过程工程研究所 > 研究所（批量导入）

	Systematic studies of Pickering emulsions stabilized by uniform-sized PLGA particles: preparation and stabilization mechanism
	Qi, Feng 1,3; Wu, Jie 1; Sun, Guanqing 2; Nan, Fangfang 1,3; Ngai, To 2; Ma, Guanghui 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2014
卷号	2 期号:43 页码:7605-7611
关键词	OIL-WATER INTERFACE MICROGEL PARTICLES SILICA PARTICLES LAPONITE CLAY MICROSPHERES RELEASE NANOPARTICLES WETTABILITY EMULSIFIER BLEOMYCIN
ISSN号	2050-750X
其他题名	J. Mat. Chem. B
中文摘要	Pickering emulsions stabilized by solid particles have been widely studied in the past decades due to improved stability and reduced use of small molecular surfactants. Recently, the application of Pickering emulsions in pharmaceutics has been attracting increasing attention but very limited practical use has been demonstrated, because most of the investigated particles possess poor biodegradability, which is inappropriate in pharmaceutics. Some reported biodegradable particles were too hydrophilic to stabilize emulsions, which needs further particle modification or additional surfactants. Fortunately, biodegradable poly(D, L-lactic-co-glycolic acid) (PLGA) with tunable hydrophilicity makes itself a promising material to prepare Pickering emulsions. However, the mechanism of emulsion stabilization still remains unknown. Moreover, fabrication of large amounts of uniform-sized and size-controlled PLGA particles by traditional methods is very difficult, which further increases the difficulty to perform the research. In the present study, we applied Shirasu Porous Glass (SPG) premix membrane emulsification to solve this problem. The stabilization mechanism of Pickering emulsions stabilized by PLGA particles was systematically studied for the first time. The factors including oil type, particle properties, concentration, molecular weight (M-w) and oil-water volume ratio were analyzed through particle wettability and interfacial influence. We found that octanol was an appropriate oil type, and its small particle size, high particle concentration and high M-w were favorable for emulsion stability. By changing the oil-water volume ratio, stable emulsions were also readily achieved. These studies proved that Pickering emulsions stabilized by PLGA particles had wide potential applications in pharmaceutics and tissue engineering.
英文摘要	Pickering emulsions stabilized by solid particles have been widely studied in the past decades due to improved stability and reduced use of small molecular surfactants. Recently, the application of Pickering emulsions in pharmaceutics has been attracting increasing attention but very limited practical use has been demonstrated, because most of the investigated particles possess poor biodegradability, which is inappropriate in pharmaceutics. Some reported biodegradable particles were too hydrophilic to stabilize emulsions, which needs further particle modification or additional surfactants. Fortunately, biodegradable poly(D, L-lactic-co-glycolic acid) (PLGA) with tunable hydrophilicity makes itself a promising material to prepare Pickering emulsions. However, the mechanism of emulsion stabilization still remains unknown. Moreover, fabrication of large amounts of uniform-sized and size-controlled PLGA particles by traditional methods is very difficult, which further increases the difficulty to perform the research. In the present study, we applied Shirasu Porous Glass (SPG) premix membrane emulsification to solve this problem. The stabilization mechanism of Pickering emulsions stabilized by PLGA particles was systematically studied for the first time. The factors including oil type, particle properties, concentration, molecular weight (M-w) and oil-water volume ratio were analyzed through particle wettability and interfacial influence. We found that octanol was an appropriate oil type, and its small particle size, high particle concentration and high M-w were favorable for emulsion stability. By changing the oil-water volume ratio, stable emulsions were also readily achieved. These studies proved that Pickering emulsions stabilized by PLGA particles had wide potential applications in pharmaceutics and tissue engineering.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Materials Science, Biomaterials
研究领域[WOS]	Materials Science
关键词[WOS]	OIL-WATER INTERFACE ; MICROGEL PARTICLES ; SILICA PARTICLES ; LAPONITE CLAY ; MICROSPHERES ; RELEASE ; NANOPARTICLES ; WETTABILITY ; EMULSIFIER ; BLEOMYCIN
收录类别	SCI
原文出处	://WOS:000343992700015
语种	英语
WOS记录号	WOS:000343992700015
公开日期	2015-04-01
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/11814]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 2.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qi, Feng,Wu, Jie,Sun, Guanqing,et al. Systematic studies of Pickering emulsions stabilized by uniform-sized PLGA particles: preparation and stabilization mechanism[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(43):7605-7611.
APA	Qi, Feng,Wu, Jie,Sun, Guanqing,Nan, Fangfang,Ngai, To,&Ma, Guanghui.(2014).Systematic studies of Pickering emulsions stabilized by uniform-sized PLGA particles: preparation and stabilization mechanism.JOURNAL OF MATERIALS CHEMISTRY B,2(43),7605-7611.
MLA	Qi, Feng,et al."Systematic studies of Pickering emulsions stabilized by uniform-sized PLGA particles: preparation and stabilization mechanism".JOURNAL OF MATERIALS CHEMISTRY B 2.43(2014):7605-7611.