Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

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	Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP
	Park, Hyungju; Popescu, Andrei; Poo, Mu-ming
刊名	NEURON
	2014
卷号	84 期号:5 页码:1009-1022
关键词	LONG-TERM POTENTIATION HIGH-FREQUENCY STIMULATION SYNAPTIC PLASTICITY NEUROTROPHIC FACTOR DORSAL STRIATUM NEUROTRANSMITTER RELEASE TRANSPORTER CURRENTS GLUTAMATE RELEASE KNOCKOUT MICE CA2+ SENSORS
通讯作者	Poo, MM (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA.
英文摘要	Activation of N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) in postsynaptic dendrites is required for long-term potentiation (LTP) of many excitatory synapses, but the role of presynaptic axonal NMDARs in synaptic plasticity remains to be clarified. Here we report that axonal NMDARs play an essential role in LTP induction at mouse corticostriatal synapses by triggering activity-induced presynaptic secretion of brain-derived neurotrophic factor (BDNF). Genetic depletion of either BDNF or the NMDAR subunit GluN1 specifically in cortical axons abolished corticostriatal LTP in response to theta burst stimulation (TBS). Furthermore, functional axonal NMDARs were required for TBS-triggered prolonged axonal Ca2+ elevation and BDNF secretion, supporting the notion that activation of axonal NMDARs induces BDNF secretion via enhancing Ca2+ signals in the presynaptic nerve terminals. These results demonstrate that presynaptic NMDARs are equally important as postsynaptic NMDARs in LTP induction of corticostriatal synapses due to their role in mediating activity-induced presynaptic BDNF secretion.
学科主题	Neurosciences
WOS标题词	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000346574300013
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2674]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Park, Hyungju,Popescu, Andrei,Poo, Mu-ming. Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP[J]. NEURON,2014,84(5):1009-1022.
APA	Park, Hyungju,Popescu, Andrei,&Poo, Mu-ming.(2014).Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP.NEURON,84(5),1009-1022.
MLA	Park, Hyungju,et al."Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP".NEURON 84.5(2014):1009-1022.