Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides

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	Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides
	Sun, JL ; Chao, J ; Huang, J ; Yin, M ; Zhang, H ; Peng, C ; Zhong, ZT ; Chen, N
刊名	ACS APPLIED MATERIALS & INTERFACES
	2014
卷号	6 期号:10 页码:7926—7932
关键词	BIOMEDICAL APPLICATIONS DNA NANOSTRUCTURES DRUG-DELIVERY BACTERIAL-DNA OLIGODEOXYNUCLEOTIDES CELLS ODN NANOPARTICLES THERAPEUTICS ACTIVATION
ISSN号	1944-8244
通讯作者	ztzhong@njau.edu.cn ; chennan@sinap.ac.cn
英文摘要	Graphene oxide (GO) has attracted more and more attention as a promising nanomaterial in biomedical research and applications. In this study, we explore the ability of GO as nanocarrier for synthetic DNA strands. Immunostimulatory CpG oligodeoxynucleotides (ODNs) are attached to Poly-L-Lysine (PLL) functionalized, polydisperse GO, or uniform small GO (sGO) nanosheets. Both types of GO-CpG ODN nanoconjugates can be delivered into murine Raw264.7 macrophages and possess immunostimulatory activity, while sGO-CpG appears to be a more efficient stimulator. In addition, sGO-CpG nanosheets exhibit higher cellular uptake but better biocompatibility compared to the larger GO-CpG counterpart. Furthermore, PLL functionalized sGO-CpG has higher immunostimulatory activity than azide functionalized sGO-CpG. Together, our studies provide evidence that sGO can be utilized as an ideal intracellular nanocarrier for synthetic single-stranded DNA, and sGO-PLL-CpG conjugates may serve as a potential proinflammatory therapeutic tool.
收录类别	SCI
语种	英语
WOS记录号	WOS:000336639200115
公开日期	2015-03-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/14540]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Sun, JL,Chao, J,Huang, J,et al. Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(10):7926—7932.
APA	Sun, JL.,Chao, J.,Huang, J.,Yin, M.,Zhang, H.,...&Chen, N.(2014).Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides.ACS APPLIED MATERIALS & INTERFACES,6(10),7926—7932.
MLA	Sun, JL,et al."Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides".ACS APPLIED MATERIALS & INTERFACES 6.10(2014):7926—7932.