Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics

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	Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics
	Wang, DF ; Fu, YM ; Yan, J ; Zhao, B ; Dai, B ; Chao, J ; Liu, HJ ; He, DN ; Zhang, Y ; Fan, CH ; Song, SP
刊名	ANALYTICAL CHEMISTRY
	2014
卷号	86 期号:4 页码:1932—1936
关键词	MAMMALIAN-CELLS HEART-FAILURE COMPUTATION IDENTIFICATION BIOMOLECULES COMPUTER
ISSN号	0003-2700
通讯作者	spsong@sinap.ac.cn
英文摘要	Molecular computing holds great promise for I diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, "+" (positive) or "-" (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations.
收录类别	SCI
语种	英语
WOS记录号	WOS:000331775600002
公开日期	2015-03-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/14248]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wang, DF,Fu, YM,Yan, J,et al. Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics[J]. ANALYTICAL CHEMISTRY,2014,86(4):1932—1936.
APA	Wang, DF.,Fu, YM.,Yan, J.,Zhao, B.,Dai, B.,...&Song, SP.(2014).Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics.ANALYTICAL CHEMISTRY,86(4),1932—1936.
MLA	Wang, DF,et al."Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics".ANALYTICAL CHEMISTRY 86.4(2014):1932—1936.