Crowdsourcing Yields a New Standard for Kinks in Protein Helices

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	Crowdsourcing Yields a New Standard for Kinks in Protein Helices
	Wilman, HR ; Ebejer, JP ; Shi, JY ; Deane, CM ; Knapp, B
刊名	JOURNAL OF CHEMICAL INFORMATION AND MODELING
	2014
卷号	54 期号:9 页码:2585—2593
关键词	TRANSMEMBRANE HELICES SECONDARY STRUCTURE MEMBRANE-PROTEINS ALPHA-HELICES PROLINE GEOMETRY RESIDUE HINGES MODEL GAME
ISSN号	1549-9596
通讯作者	knapp@stats.ox.ac.uk
英文摘要	Kinks are functionally important structural features found in the a-helices of proteins. Structurally, they are points at which a helix abruptly changes direction. Current kink definition and identification methods often disagree with one another. Here we describe a crowdsourcing approach to obtain a reliable gold standard set of kinks. Using an online interface, we collected more than 10 000 classifications of 300 helices into straight, curved, or kinked categories. We found that participants were better at discriminating between straight and not-straight helices than between kinked and curved helices. Surprisingly, more obvious kinks were not necessarily identified as more localized within the helix. We present a set of 252 helices where more than 50% of the participants agree on a classification. This set can be used as a reliable gold standard to develop, train, and compare computational methods. An interactive visualization of the results is available online at http://opig.stats.ox.ac.uk/webapps/ahah/php/experiment_results.php.
收录类别	SCI
语种	英语
WOS记录号	WOS:000342180400017
公开日期	2015-03-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/14061]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wilman, HR,Ebejer, JP,Shi, JY,et al. Crowdsourcing Yields a New Standard for Kinks in Protein Helices[J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING,2014,54(9):2585—2593.
APA	Wilman, HR,Ebejer, JP,Shi, JY,Deane, CM,&Knapp, B.(2014).Crowdsourcing Yields a New Standard for Kinks in Protein Helices.JOURNAL OF CHEMICAL INFORMATION AND MODELING,54(9),2585—2593.
MLA	Wilman, HR,et al."Crowdsourcing Yields a New Standard for Kinks in Protein Helices".JOURNAL OF CHEMICAL INFORMATION AND MODELING 54.9(2014):2585—2593.