Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals
	Liang, Xuefang ; Martyniuk, Christopher J. ; Cheng, Gang ; Zha, Jinmiao ; Wang, Zijian
刊名	ENVIRONMENTAL POLLUTION
	2014
卷号	189 期号:1 页码:184-193
关键词	Protein biomarker Pyruvate carboxylase Exogenous steroid chemicals Rare minnow
ISSN号	0269-7491
中文摘要	Assessing protein responses to endocrine disrupting chemicals is critical for understanding the mechanisms of chemical action and for the assessment of hazards. In this study, the response of the liver proteome of male rare minnows (Gobiocypris rarus) treated with 17 beta-estradiol (E2) and females treated with 17 alpha-methyltestosterone (MT) were analyzed. A total of 23 and 24 proteins were identified with differential expression in response to E2 and MT, respectively. Pyruvate carboxylase (PC) was the only common differentially expressed protein in both males and females after E2- and MT-treatments. The mRNA as well as the protein levels of PC were significantly down-regulated compared with that of the controls (p < 0.05). Our results suggest that endocrine disruptors interfere with genes and proteins of the TCA cycle and PC may be a sensitive biomarker of exposure to exogenous steroid chemicals in the liver of fish. (C) 2014 Elsevier Ltd. All rights reserved.
WOS记录号	WOS:000336466900024
公开日期	2015-03-26
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9588]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Liang, Xuefang,Martyniuk, Christopher J.,Cheng, Gang,et al. Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals[J]. ENVIRONMENTAL POLLUTION,2014,189(1):184-193.
APA	Liang, Xuefang,Martyniuk, Christopher J.,Cheng, Gang,Zha, Jinmiao,&Wang, Zijian.(2014).Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals.ENVIRONMENTAL POLLUTION,189(1),184-193.
MLA	Liang, Xuefang,et al."Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals".ENVIRONMENTAL POLLUTION 189.1(2014):184-193.