Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin | |
Song, Wantong ; Tang, Zhaohui ; Zhang, Dawei ; Zhang,Ying ; Yu,Haiyang ; Li,Mingqiang ; Lv,Shixian ; Sun,Hai ; Deng,Mingxiao ; Chen,Xuesi | |
刊名 | biomaterials |
2014 | |
卷号 | 35期号:9页码:3005-3014 |
关键词 | CELL LUNG-CANCER DRUG-DELIVERY BREAST-CANCER LIPOSOMAL DOXORUBICIN MULTIDRUG-RESISTANCE COMBINATION THERAPY CREMOPHOR-FREE GENE DELIVERY PACLITAXEL TUMOR |
ISSN号 | 0142-9612 |
通讯作者 | tang,zh |
中文摘要 | there are two important obstacles for the currently applied anti-cancer drug delivery systems. one is the conflict between long-circulation and cellular uptake while the other one is the achievement of ideal anti-cancer efficacy. to solve these problems, we designed a polypeptide-based micelle system that combined the advantages of receptor mediated endocytosis and multi-drug delivery. firstly, an amphiphilic plg-g-ve/peg graft copolymer was prepared by grafting alpha-tocopherol (ve) and polyethylene glycol (peg) to poly(l-glutamic acid) (plc). then docetaxel (dtx) and cisplatin (cddp) were co-loaded into the plg-g-ve/peg micelles via hydrophobic and chelation effect. after that, the surface of the dual-drug-loaded micelles was decorated with an alpha(v)beta(3) integrin targeting peptide c(rgdfk). the targeted dual-drug-loaded micelles showed synergistic cytotoxicity and enhanced internalization rate in mouse melanoma (b16f1) cells. in vivo tests demonstrated that remarkable long circulation, anti-tumor and anti-metastasis efficacy could be achieved using this drug delivery system. this work revealed a strategy for the design and preparation of anti-cancer drug delivery systems with reduced side effect, enhanced anti-tumor and anti-metastasis efficacy. (c) 2013 elsevier ltd. all rights reserved. |
收录类别 | SCI收录期刊论文 |
语种 | 英语 |
WOS记录号 | WOS:000332188900044 |
公开日期 | 2015-03-25 |
内容类型 | 期刊论文 |
源URL | [http://ir.ciac.jl.cn/handle/322003/50669] |
专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
推荐引用方式 GB/T 7714 | Song, Wantong,Tang, Zhaohui,Zhang, Dawei,et al. Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin[J]. biomaterials,2014,35(9):3005-3014. |
APA | Song, Wantong.,Tang, Zhaohui.,Zhang, Dawei.,Zhang,Ying.,Yu,Haiyang.,...&Chen,Xuesi.(2014).Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin.biomaterials,35(9),3005-3014. |
MLA | Song, Wantong,et al."Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin".biomaterials 35.9(2014):3005-3014. |
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